Mammalian CPEB3 ribozyme

The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation.[1] This ribozyme is highly conserved and found only in mammals.[1] The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus ribozyme.[2] Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.[3]

Mammalian CPEB3 ribozyme
Predicted secondary structure and sequence conservation of CPEB3_ribozyme
Identifiers
SymbolCPEB3_ribozyme
RfamRF00622
Other data
RNA typeGene; ribozyme
Domain(s)Eukaryota
SOSO:0000374
PDB structuresPDBe

References

  1. Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW (2006). "A genomewide search for ribozymes reveals an HDV-like sequence in thehuman CPEB3 gene". Science. 313 (5794): 1788–1792. doi:10.1126/science.1129308. PMID 16990549. S2CID 43309772.
  2. Chadalavada DM, Gratton EA, Bevilacqua PC (2010). "The Human HDV-like CPEB3 Ribozyme Is Intrinsically Fast-Reacting". Biochemistry. 49 (25): 5321–5330. doi:10.1021/bi100434c. PMC 2890282. PMID 20524672.
  3. Webb, CH; Riccitelli, NJ; Ruminski, DJ; Lupták, A (Nov 13, 2009). "Widespread occurrence of self-cleaving ribozymes". Science. 326 (5955): 953. doi:10.1126/science.1178084. PMC 3159031. PMID 19965505.
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