Metallothionein-3

Metallothionein-3 (also known as Growth Inhibitory Factor) is a protein that in humans is encoded by the MT3 gene.[3][4][5] It is a 68-amino acid peptide (20 of which are cysteine) that is abnormally under-expressed in the brains of patients suffering from Alzheimer's disease.[6] Metallothionein-3 is a member of the metallothionein family of proteins.

MT3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMT3, GIF, GIFB, GRIF, Znmetallothionein 3
External IDsOMIM: 139255 HomoloGene: 136800 GeneCards: MT3
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q13Start56,589,074 bp[1]
End56,591,088 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4504

n/a

Ensembl

ENSG00000087250

n/a

UniProt

P25713

n/a

RefSeq (mRNA)

NM_005954

n/a

RefSeq (protein)

NP_005945

n/a

Location (UCSC)Chr 16: 56.59 – 56.59 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

References

  1. GRCh38: Ensembl release 89: ENSG00000087250 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Palmiter RD, Findley SD, Whitmore TE, Durnam DM (Jul 1992). "MT-III, a brain-specific member of the metallothionein gene family". Proceedings of the National Academy of Sciences of the United States of America. 89 (14): 6333–7. doi:10.1073/pnas.89.14.6333. PMC 49495. PMID 1631128.
  4. Felizola SJ, Nakamura Y, Arata Y, Ise K, Satoh F, Rainey WE, Midorikawa S, Suzuki S, Sasano H (Sep 2014). "Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders". Endocrine Pathology. 25 (3): 229–235. doi:10.1007/s12022-013-9280-9. PMID 24242700. S2CID 39871076.
  5. "Entrez Gene: MT3 metallothionein 3".
  6. Uchida, Y; Takio, K; Titani, K; Ihara, Y; Tomonaga, M (August 1991). "The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein". Neuron. 7 (2): 337–347. doi:10.1016/0896-6273(91)90272-2. PMID 1873033. S2CID 25819090.

Further reading


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