Michael Roden

Michael Roden (born February 11, 1961) is Professor and Chairman of Internal Medicine, Endocrinology and Metabolic Disorders at Heinrich Heine University Düsseldorf (HHU), Director of the Division of Endocrinology and Diabetology at the University Hospital of Düsseldorf (UKD) and Spokesman for the Executive Board and Scientific Director of the German Diabetes Center (DDZ), the Leibniz Center for Diabetes Research at the Heinrich Heine University Düsseldorf (Legal body: Deutsche Diabetes-Forschungsgesellschaft eV).

Michael Roden

Career and appointments

After finishing high school at Akademisches Gymnasium Vienna, Austria, and study of medicine in 1986 at the University of Vienna, he started his career as an assistant at the Pharmacological Institute.  In 1988, he began working at the 1st Medical University Clinic of the University of Vienna, where he acquired the “venia legendi” in Internal Medicine in 1994. He then worked as Max-Kade Fellow in the Section of Endocrinology at Yale University in 1994/1995. After returning to the Division for Endocrinology and Metabolism at the University Clinic of Internal Medicine III at the General Hospital Vienna as a senior physician, he was appointed as Associate Professor in 1997. From 2003 to 2009, he served as chairman and director of the 1st Medical Department including the Division of Nephrology at Hanusch Hospital, Teaching Hospital of the Medical University of Vienna. In 2005, he founded the Karl Landsteiner Institute for Endocrinology and Metabolic Diseases. After accepting the call as chairman and professor in Düsseldorf, he became a board member of the German Center for Diabetes Research (DZD e.V.) in 2009. In 2016, he was appointed by the Federal President of Germany as a member of the Science Council of the Federal Government and the Governments of the federal states of Germany. Since 2017, he has been contributing his knowledge and experience there as Chairman of its Medical Committee.[1] As President, he led the 54th annual meeting of the German Diabetes Association (DDG) in 2019 with the slogan "Diabetes - Not only a question of type".[2]

Research contributions

Michael Roden’s research focusses on energy metabolism in humans under physiological conditions and with metabolic disorders such as metabolic syndrome, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD / NASH). [3][4] He has made major contributions to our understanding of the cellular mechanisms of fatty acid-[5][6][7][8] and amino acid-induced insulin resistance in humans.[9] Additionally, he examined the function of mitochondria (Link) in muscle and liver tissue. With his research group, he is contributing to the development of novel non-invasive methods for real-time analysis of tissue-specific metabolism.[10][11] His studies demonstrated that alterations of mitochondrial function can decisively influence the development and progress of diabetes and NAFLD.[12][13] His recent research contributes to a novel differentiation of diabetes subtypes with various risks for their sequelae and promotes the way to precision medicine for people with diabetes.[14]

Roden is the author of more than 500 "peer-reviewed" publications, co-author of (inter)national guidelines[15][16][17] and the editor of the book "Clinical Diabetes Research: Methods and Techniques".[18] According to the Scopus database, it has an h-index of 77.

Selected honors/affiliations/awards
  • 2001 Ferdinand-Bertram Award of the German Diabetes Society (DDG)
  • 2001 Novartis (Sandoz) Award for Chemistry, Biology, Medicine, Austria
  • 2004 International Novartis Award for Innovative Patient Oriented Research
  • 2006 ESCI (Mack-Foster) Award for Excellence in Clinical Sciences
  • 2006 Oskar-Minkowski Award of the European Association for the Study of Diabetes (EASD)
  • 2013 Honorary doctorate from the Medical Faculty of the University of Belgrade
  • 2014 Somogyi Award of the Hungarian Diabetes Society (Magyar Diabetes Társaság)
  • 2016 Honorary doctorate from the Medical Faculty of the National and Kapodistrian University Athens
  • 2017 Paul-Langerhans Medal of the German Diabetes Society (DDG)[19]
  • 2018 G. B. Morgagni Prize and Gold Medal Career Achievement[20]
  • 2019 Scientific Advisory Board of the Medical University of Vienna, Austria

Selected works

Guidelines
  • Norbert Stefan, Michael Roden: Diabetes and Fatty Liver. In: Experimental and Clinical Endocrinology & Diabetes. 127, Nr. S 01, 2019, ISSN 0947-7349, S. S93–S96. DOI: 10.1055/a-0984-5753
  • EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. In: Journal of Hepatology. 64, Nr. 6, 2016, ISSN 0168-8278, S. 1388–1402. DOI:10.1016/j.jhep.2015.11.004.

Books
  • Michael Roden: Clinical Diabetes Research: Methods and Techniques. John Wiley & Sons, Chichester, West Sussex, England Hoboken, NJ 2007, ISBN 978-0-470-01728-9.

Publications
  • Roden, M, Shulman, GI, 2019. Integrative biology of type 2 diabetes. Nature, Bd. 576, S. 51–60. DOI: 10.1038/s41586-019-1797-8
  • Gancheva, S, Ouni, M, Jelenik, T, Koliaki, C, Szendroedi, J, Markgraf, D, de Fillipo, E, Herder, C, Jähnert, M, Strassburger, K, Schlensak, M, Schürmann, A & Roden, M, 2019. Dynamic changes of muscle insulin senstivity after metabolic surgery. Nat. Commun., Bd. 10, S. 4179. DOI: 10.1038/s41467-019-12081-0
  • Zaharia, OP, Strassburger, K, Strom, A, Bönhof, GJ, Karusheva, Y, Antoniou, S, Bódis, K, Markgraf, DF, Burkart, V, Müssig, K, Hwang, JH, Asplund, O, Groop, L, Ahlqvist, E, Seissler, J, Nawroth, P, Kopf, S, Schmid, SM, Stumvoll, M, Pfeiffer, AFH, Kabisch, S, Tselmin, S, Häring, HU, Ziegler, D, Kuss, O, Szendroedi, J, Roden, M, 2019. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol., Bd. 7, Nr. 9, S. 657–736. DOI: 10.1016/S2213-8587(19)30187-1
  • Gancheva, S, Jelenik, T, Álvarez-Hernández, E, Roden, M, 2018. Interorgan Metabolic Crosstalk in Human Insulin Resistance. Physiological Reviews. 98, Nr. 3, 2018, ISSN 0031-9333, S. 1371–1415. DOI:10.1152/physrev.00015.2017
  • Álvarez-Hernández, E, Kahl, S, Seelig, A, Begovatz, P, Irmler, M, Kupriyanova, Y, Nowotny, B, Nowotny, P, Herder, C, Barosa, C, Carvalho, F, Rozman, J, Neschen, S, Jones, JG, Beckers, J, de Angelis, MH & Roden, M, 2017. Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J. Clin. Invest., Bd. 127, Nr. 2, S. 695–708. DOI: 10.1172/JCI89444
  • Koliaki, C, Szendroedi, J, Kaul, K, Jelenik, T, Nowotny, P, Jankowiak, F, Herder, C, Carstensen, M, Krausch, M, Knoefel, WT, Schlensak, M & Roden, M, 2015. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab., Bd. 21, Nr. 5, S. 739–46. DOI: 10.1016/j.cmet.2015.04.004
  • Szendroedi, J, Yoshimura, T, Phielix, E, Koliaki, C, Marcucci, M, Zhang, D, Jelenik, T, Müller, J, Herder, C, Nowotny, P, Shulman, GI, Roden, M, 2014. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proceedings of the National Academy of Sciences. 111, Nr. 26, ISSN 0027-8424, S. 9597–9602. DOI: 10.1073/pnas.1409229111
  • Schmid, AI, Szendroedi, J, Chmelik, M, Krssak, M, Moser, E, Roden, M, 2011. Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes. Diabetes Care. 34, Nr. 2, ISSN 0149-5992, S. 448–453. DOI:10.2337/dc10-1076
  • Krebs, M, Krssak, M, Bernroider, E, Anderwald, C, Brehm, A, Meyerspeer, M, Nowotny, P, Roth, E, Waldhausl, W, Roden, R, 2002 Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans. In: Diabetes. 51, Nr. 3, ISSN 0012-1797, S. 599–605. DOI:10.2337/diabetes.51.3.599
  • Roden, M, Krssak, M, Stingl, H, Gruber, S, Hofer, A, Furnsinn, C, Moser, E, Waldhausl, W, 1999. Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes. 48, Nr. 2, ISSN 0012-1797, S. 358–364. DOI: 10.2337/diabetes.48.2.358

References
  1. "Wissenschaftsrat - Medizin". www.wissenschaftsrat.de. Retrieved 2020-02-04.
  2. "Deutsche Diabetes Gesellschaft: Deutsche Diabetes Gesellschaft mit 54. Diabetes Kongress in Berlin: Diabetesklassifikation, Remission und genderbezogene Aspekte". www.deutsche-diabetes-gesellschaft.de. Retrieved 2020-02-04.
  3. Gancheva, Sofiya; Jelenik, Tomas; Álvarez-Hernández, Elisa; Roden, Michael (2018). "Interorgan Metabolic Crosstalk in Human Insulin Resistance". Physiological Reviews. 98 (3): 1371–1415. doi:10.1152/physrev.00015.2017. ISSN 0031-9333.
  4. Hernández, Elisa Álvarez; Kahl, Sabine; Seelig, Anett; Begovatz, Paul; Irmler, Martin; Kupriyanova, Yuliya; Nowotny, Bettina; Nowotny, Peter; Herder, Christian; Barosa, Cristina; Carvalho, Filipa; Rozman, Jan; Neschen, Susanne; Jones, John G.; Beckers, Johannes; de Angelis, Martin Hrabě; Roden, Michael (2017). "Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance". Journal of Clinical Investigation. 127 (2): 695–708. doi:10.1172/JCI89444. ISSN 0021-9738.
  5. Stefan, Norbert; Roden, Michael (2019). "Diabetes and Fatty Liver". Experimental and Clinical Endocrinology & Diabetes. 127 (S 01): S93–S96. doi:10.1055/a-0984-5753. ISSN 0947-7349.
  6. Apostolopoulou, Maria; Gordillo, Ruth; Koliaki, Chrysi; Gancheva, Sofia; Jelenik, Tomas; De Filippo, Elisabetta; Herder, Christian; Markgraf, Daniel; Jankowiak, Frank; Esposito, Irene; Schlensak, Matthias; Scherer, Philipp E.; Roden, Michael (2018). "Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis". Diabetes Care. 41 (6): 1235–1243. doi:10.2337/dc17-1318. ISSN 0149-5992.
  7. Szendroedi, Julia; Yoshimura, Toru; Phielix, Esther; Koliaki, Chrysi; Marcucci, Mellissa; Zhang, Dongyan; Jelenik, Tomas; Müller, Janette; Herder, Christian; Nowotny, Peter; Shulman, Gerald I.; Roden, Michael (2014). "Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans". Proceedings of the National Academy of Sciences. 111 (26): 9597–9602. doi:10.1073/pnas.1409229111. ISSN 0027-8424.
  8. Roden, M.; Krssak, M.; Stingl, H.; Gruber, S.; Hofer, A.; Furnsinn, C.; Moser, E.; Waldhausl, W. (1999). "Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans". Diabetes. 48 (2): 358–364. doi:10.2337/diabetes.48.2.358. ISSN 0012-1797.
  9. Krebs, M.; Krssak, M.; Bernroider, E.; Anderwald, C.; Brehm, A.; Meyerspeer, M.; Nowotny, P.; Roth, E.; Waldhausl, W.; Roden, M. (2002). "Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans". Diabetes. 51 (3): 599–605. doi:10.2337/diabetes.51.3.599. ISSN 0012-1797.
  10. Schmid, A. I.; Szendroedi, J.; Chmelik, M.; Krssak, M.; Moser, E.; Roden, M. (2011). "Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes". Diabetes Care. 34 (2): 448–453. doi:10.2337/dc10-1076. ISSN 0149-5992.
  11. Kunert, O.; Stingl, H.; Rosian, E.; Krssak, M.; Bernroider, E.; Seebacher, W.; Zangger, K.; Staehr, P.; Chandramouli, V.; Landau, B.R.; Nowotny, P.; Waldhausl, W.; Haslinger, E.; Roden, M. (2003). "Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using 2H Nuclear Magnetic Resonance Spectroscopy". Diabetes. 52 (10): 2475–2482. doi:10.2337/diabetes.52.10.2475. ISSN 0012-1797.
  12. Gancheva, Sofiya; Ouni, Meriem; Jelenik, Tomas; Koliaki, Chrysi; Szendroedi, Julia; Toledo, Frederico G. S.; Markgraf, Daniel F.; Pesta, Dominik H.; Mastrototaro, Lucia; De Filippo, Elisabetta; Herder, Christian; Jähnert, Markus; Weiss, Jürgen; Strassburger, Klaus; Schlensak, Matthias; Schürmann, Annette; Roden, Michael (2019). "Dynamic changes of muscle insulin sensitivity after metabolic surgery". Nature Communications. 10 (1). doi:10.1038/s41467-019-12081-0. ISSN 2041-1723.
  13. Koliaki, Chrysi; Szendroedi, Julia; Kaul, Kirti; Jelenik, Tomas; Nowotny, Peter; Jankowiak, Frank; Herder, Christian; Carstensen, Maren; Krausch, Markus; Knoefel, Wolfram Trudo; Schlensak, Matthias; Roden, Michael (2015). "Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis". Cell Metabolism. 21 (5): 739–746. doi:10.1016/j.cmet.2015.04.004. ISSN 1550-4131.
  14. Zaharia, Oana P; Strassburger, Klaus; Strom, Alexander; Bönhof, Gidon J; Karusheva, Yanislava; Antoniou, Sofia; Bódis, Kálmán; Markgraf, Daniel F; Burkart, Volker; Müssig, Karsten; Hwang, Jong-Hee; Asplund, Olof; Groop, Leif; Ahlqvist, Emma; Seissler, Jochen; Nawroth, Peter; Kopf, Stefan; Schmid, Sebastian M; Stumvoll, Michael; Pfeiffer, Andreas F H; Kabisch, Stefan; Tselmin, Sergey; Häring, Hans U; Ziegler, Dan; Kuss, Oliver; Szendroedi, Julia; Roden, Michael (2019). "Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study". The Lancet Diabetes & Endocrinology. 7 (9): 684–694. doi:10.1016/S2213-8587(19)30187-1. ISSN 2213-8587.
  15. Stefan, Norbert; Roden, Michael (2019). "Diabetes and Fatty Liver". Experimental and Clinical Endocrinology & Diabetes. 127 (S 01): S93–S96. doi:10.1055/a-0984-5753. ISSN 0947-7349.
  16. Harreiter, Jürgen; Roden, Michael (2019). "Diabetes mellitus – Definition, Klassifikation, Diagnose, Screening und Prävention (Update 2019)". Wiener klinische Wochenschrift. 131 (S1): 6–15. doi:10.1007/s00508-019-1450-4. ISSN 0043-5325.
  17. "EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease". Journal of Hepatology. 64 (6): 1388–1402. 2016. doi:10.1016/j.jhep.2015.11.004. ISSN 0168-8278.
  18. Roden, Michael (2007). Clinical diabetes research : methods and techniques. Chichester, West Sussex, England Hoboken, NJ: John Wiley & Sons. ISBN 9780470017289.
  19. "Deutsche Diabetes Gesellschaft: Träger der Paul-Langerhans-Medaille". www.deutsche-diabetes-gesellschaft.de. Retrieved 2020-02-04.
  20. "Professor Michael Roden erhält Morgagni Goldmedaille 2018 - Deutsches Diabetes-Zentrum (DDZ)". ddz.de. Retrieved 2020-02-04.
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