N-Iodosuccinimide

N-Iodosuccinimide
Names
	IUPAC name 1-Iodo-2,5-pyrrolidinedione
Identifiers
CAS Number	516-12-1;
3D model (JSmol)	Interactive image;
Beilstein Reference	113917
ChEBI	CHEBI:53204;
ChemSpider	107372;
ECHA InfoCard	100.007.475
EC Number	208-221-6;
Gmelin Reference	122896
PubChem CID	120273;
UNII	3COS3X3N4P;
CompTox Dashboard (EPA)	DTXSID10199550 ;
	InChI InChI=1S/C4H4INO2/c5-6-3(7)1-2-4(6)8/h1-2H2 Key: LQZMLBORDGWNPD-UHFFFAOYSA-N;
	SMILES C1CC(=O)N(C1=O)I;
Properties
Chemical formula	C4H4INO2
Molar mass	224.985 g·mol−1
Appearance	White solid
Density	2.245 g/cm3
Melting point	202–206 °C (396–403 °F; 475–479 K)(dec.) [1]
Solubility in water	Soluble in Dioxane, THF, MeCN; Insoluble in ether, CCl4
Hazards
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H302, H315, H319, H335
GHS precautionary statements	P261, P264, P270, P271, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P403+233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

N-Iodosuccinimide (NIS) is a reagent used in organic chemistry for the iodination of alkenes and as a mild oxidant.[2][3]

NIS is the iodine analog of N-chlorosuccinimide (NCS) and N-bromosuccinimide (NBS) which are used for similar applications.

References

"N-Iodosuccinimide". Sigma-Aldrich.
Scott C. Virgil; Zeng, Ying; Kong, Fanzuo; Pigza, Julie A. (2001). "N-Iodosuccinimide". E-EROS Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.ri038.pub3. ISBN 0471936235.
"N-Iodosuccinimide - Huateng Pharma".

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