N-acetyl-D-glucosamine kinase

N-acetyl-D-glucosamine kinase is an enzyme that in humans is encoded by the NAGK gene.[1][2]

N-acetyl-D-glucosamine kinase
Identifiers
AliasesN-acetyl-D-glucosamine_kinaseIPR023505
External IDsGeneCards:
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Function

N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.[supplied by OMIM][2]

Interactions

NAGK has been shown to interact with STK16[3] and LNX1.[4]

References

  1. Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W (Jun 2000). "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase". European Journal of Biochemistry / FEBS. 267 (11): 3301–8. doi:10.1046/j.1432-1327.2000.01360.x. PMID 10824116.
  2. "Entrez Gene: NAGK N-acetylglucosamine kinase".
  3. Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A (Feb 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". The Journal of Biological Chemistry. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.
  4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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