N-sulfoglucosamine sulfohydrolase
In enzymology, a N-sulfoglucosamine sulfohydrolase (EC 3.10.1.1) is an enzyme that catalyzes the chemical reaction
- N-sulfo-D-glucosamine + H2O D-glucosamine + sulfate
| N-sulfoglucosamine sulfohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.10.1.1 | ||||||||
| CAS number | 37289-41-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are N-sulfo-D-glucosamine and H2O, whereas its two products are D-glucosamine and sulfate.
This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is N-sulfo-D-glucosamine sulfohydrolase. Other names in common use include sulfoglucosamine sulfamidase, heparin sulfamidase, 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate, and sulphohydrolase). This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.
This enzyme can also be found at SGSH
References
- Dietrich CP (1969). "Enzymic degradation of heparin A sulphamidase and a sulphoesterase from Flavobacterium heparinum". Biochem. J. 111 (1): 91–5. PMC 1187498. PMID 5775690.
- Mahuran D, Clements P, Hopwood J (1983). "A rapid four column purification of 2-deoxy-D-glucoside-2-sulphamate sulphohydrolase from human liver". Biochim. Biophys. Acta. 757 (3): 359–65. doi:10.1016/0304-4165(83)90062-4. PMID 6849981.
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