NADH:ubiquinone reductase (Na+-transporting)

NADH:ubiquinone reductase (Na+-transporting) (EC 1.6.5.8 is an enzyme with systematic name NADH:ubiquinone oxidoreductase (Na+-translocating). In bacteria, three different types of respiratory NADH:quinone oxidoreductases (NQr) have been described: the electrogenic complex I, also called NDH I in bacteria, the non-electrogenic NADH:quinone oxidoreductases (NDH II), and the Na+-translocating NADH:quinone oxidoreductases Na+-NQr. The common function of these transmembrane enzymes in respiration is to oxidize NADH using ubiquinone (Q) as electron acceptor. The net reaction thus yields ubiquinol (QH2), the reducing substrate of enzyme complexes further along the respiratory chain, and NAD+, which is used as oxidizing agent in numerous cellular processes.[1]

NADH + H+ + ubiquinone + n Na+in → NAD+ + ubiquinol + n Na+out
Na(+)-translocating NADH-quinone reductase
Identifiers
SymbolNQR
PfamPF03116
TCDB3.D.5
OPM superfamily372
OPM protein4pbv
NADH:ubiquinone reductase (Na+-transporting)
Identifiers
EC number1.6.5.8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme is iron-sulfur flavoprotein.

References
  1. Fritz G, Steuber J (2016). "Chapter 11: Sodium as Coupling Cation in Respiratory Energy Conversion". In Astrid S, Helmut S, Roland S (eds.). The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. 16. Springer. pp. 349–390. doi:10.1007/978-4-319-21756-7_11 (inactive 2021-01-30).CS1 maint: DOI inactive as of January 2021 (link)
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