NCDN

Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene.[5][6]

NCDN
Identifiers
AliasesNCDN, neurochondrin
External IDsOMIM: 608458 MGI: 1347351 HomoloGene: 8064 GeneCards: NCDN
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p34.3Start35,557,473 bp[1]
End35,567,274 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23154

26562

Ensembl

ENSG00000020129

ENSMUSG00000028833

UniProt

Q9UBB6

Q9Z0E0

RefSeq (mRNA)

NM_014284
NM_001014839
NM_001014841

NM_011986
NM_001355412
NM_001355413

RefSeq (protein)

NP_001014839
NP_001014841
NP_055099

NP_036116
NP_001342341
NP_001342342

Location (UCSC)Chr 1: 35.56 – 35.57 MbChr 4: 126.74 – 126.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.[6]

Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.[7] Furthermore, norbin protein expression is altered in the schizophrenia brain.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000020129 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028833 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Istvánffy R, Vogt Weisenhorn DM, Floss T, Wurst W (Apr 2004). "Expression of neurochondrin in the developing and adult mouse brain". Development Genes and Evolution. 214 (4): 206–9. doi:10.1007/s00427-004-0396-2. PMID 15007648. S2CID 45134242.
  6. "Entrez Gene: NCDN neurochondrin".
  7. Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, Nestler E, Aperia A, Flajolet M, Greengard P (Dec 2009). "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling". Science. 326 (5959): 1554–7. Bibcode:2009Sci...326.1554W. doi:10.1126/science.1178496. PMC 2796550. PMID 20007903.
  8. Matosin N, Fernandez-Enright F, Fung SJ, Lum JS, Engel M, Andrews JL, Huang XF, Weickert CS, Newell KA (Jul 2015). "Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation". Acta Neuropathologica. 130 (1): 119–29. doi:10.1007/s00401-015-1411-6. PMID 25778620. S2CID 12360955.

Further reading


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