NDRG4

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.[5][6][7]

NDRG4
Identifiers
AliasesNDRG4, BDM1, SMAP-8, SMAP8, NDRG family member 4
External IDsOMIM: 614463 MGI: 2384590 HomoloGene: 23228 GeneCards: NDRG4
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q21Start58,462,846 bp[1]
End58,513,628 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

65009

234593

Ensembl

ENSG00000103034

ENSMUSG00000036564

UniProt

Q9ULP0

Q8BTG7

RefSeq (mRNA)

NM_001195006
NM_145602

RefSeq (protein)
Location (UCSC)Chr 16: 58.46 – 58.51 MbChr 8: 95.68 – 95.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000103034 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036564 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
  6. Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem. 98 (1): 185–93. doi:10.1002/jcb.20763. PMID 16408304. S2CID 10192022.
  7. "Entrez Gene: NDRG4 NDRG family member 4".

Further reading


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