NKIRAS2

NKIRAS2
Identifiers
Aliases	NKIRAS2, KBRAS2, kappaB-Ras2, NFKB inhibitor interacting Ras like 2
External IDs	OMIM: 604497 MGI: 1919216 HomoloGene: 9738 GeneCards: NKIRAS2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	42,025,644 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	100,627,607 bp[2]
Gene ontology
Molecular function	• nucleotide binding; • GTP binding; • GTPase activity;
Cellular component	• cytoplasm; • membrane; • cellular component;
Biological process	• I-kappaB kinase/NF-kappaB signaling; • signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	28511
	71966
	ENSG00000168256
	ENSMUSG00000017837
	Q9NYR9
	Q9CR56
	NM_001001349; NM_001144927; NM_001144928; NM_001144929; NM_017595
	NM_028024
NP_001001349; NP_001138399; NP_001138400; NP_001138401; NP_060065;
	NP_001001349.1; NP_001138399.1; NP_060065.2
	NP_082300
	Wikidata
View/Edit Human	View/Edit Mouse

NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.[5]

Model organisms

*Nkiras2* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Salmonella infection	Normal[6]
All tests and analysis from[7]

Model organisms have been used in the study of NKIRAS2 function. A conditional knockout mouse line, called Nkiras2^{tm1a(EUCOMM)Wtsi}[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][13] Twenty one tests were carried out, but no significant abnormalities were observed.[7]

References

GRCh38: Ensembl release 89: ENSG00000168256 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000017837 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30.
"Salmonella infection data for Nkiras2". Wellcome Trust Sanger Institute.
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
"International Knockout Mouse Consortium".
"Mouse Genome Informatics".
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Tago K, Funakoshi-Tago M, Sakinawa M, Mizuno N, Itoh H (Oct 2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA". The Journal of Biological Chemistry. 285 (40): 30622–33. doi:10.1074/jbc.M110.117028. PMC 2945557. PMID 20639196.
Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (Feb 2000). "A subclass of Ras proteins that regulate the degradation of IkappaB". Science. 287 (5454): 869–73. doi:10.1126/science.287.5454.869. PMID 10657303.
Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A (Apr 2009). "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis". Annals of the Rheumatic Diseases. 68 (4): 579–83. doi:10.1136/ard.2007.087304. PMID 18434448. S2CID 24874869.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168256 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017837 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30.

[''Salmonella''_infection-6] "Salmonella infection data for Nkiras2". Wellcome Trust Sanger Institute.

[mgp_reference-7] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[allele_ref-8] "International Knockout Mouse Consortium".

[mgi_allele_ref-9] "Mouse Genome Informatics".

[pmid21677750-10] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-11] Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-12] Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.

[pmid21722353-13] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

NKIRAS2

Model organisms

References

Further reading