NME2

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.[5][6]

NME2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF, NME/NM23 nucleoside diphosphate kinase 2
External IDsOMIM: 156491 MGI: 97356 HomoloGene: 133879 GeneCards: NME2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.33Start51,165,435 bp[1]
End51,171,747 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4831

18103

Ensembl

ENSG00000243678

ENSMUSG00000020857

UniProt

P22392

Q01768

RefSeq (mRNA)

NM_002512
NM_001018137
NM_001018138
NM_001018139
NM_001198682

NM_001077529
NM_008705

RefSeq (protein)

NP_001070997
NP_032731

Location (UCSC)Chr 17: 51.17 – 51.17 MbChr 11: 93.95 – 93.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.[6]

Interactions

NME2 has been shown to interact with NME3[7][8] and HERC5.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000243678 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020857 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS (February 1991). "Identification of a second human nm23 gene, nm23-H2". Cancer Res. 51 (1): 445–9. PMID 1988104.
  6. "Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in".
  7. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  8. Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
  9. Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J (July 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. PMID 18535780. S2CID 6897759.

Further reading


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