NPM3
Nucleoplasmin-3 is a protein that in humans is encoded by the NPM3 gene.[5][6]
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| Aliases | NPM3, PORMIN, TMEM123, nucleophosmin/nucleoplasmin 3 | ||||||||||||||||||||||||
| External IDs | OMIM: 606456 MGI: 894653 HomoloGene: 5083 GeneCards: NPM3 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 10: 101.78 – 101.78 Mb | Chr 19: 45.75 – 45.75 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may represent a new member of this gene family, and may share basic functions with the molecular chaperones.[6]
References
- GRCh38: Ensembl release 89: ENSG00000107833 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000056209 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi:10.1186/1471-2164-2-8. PMC 60000. PMID 11722795.
- "Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".
Further reading
- Philpott A, Krude T, Laskey RA (2000). "Nuclear chaperones". Semin. Cell Dev. Biol. 11 (1): 7–14. doi:10.1006/scdb.1999.0346. PMID 10736259.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- MacArthur CA, Shackleford GM (1997). "Npm3: a novel, widely expressed gene encoding a protein related to the molecular chaperones nucleoplasmin and nucleophosmin". Genomics. 42 (1): 137–40. doi:10.1006/geno.1997.4353. PMID 9177783.
External links
- NPM3 human gene location in the UCSC Genome Browser.
- NPM3 human gene details in the UCSC Genome Browser.
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