NUDT4

NUDT4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DUK
Identifiers
Aliases	NUDT4, DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, nudix hydrolase 4, DIPP-2B, NUDT4B
External IDs	OMIM: 609229 MGI: 1918457 HomoloGene: 41726 GeneCards: NUDT4
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	93,408,146 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	95,564,146 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• inositol diphosphate tetrakisphosphate diphosphatase activity; • inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; • inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; • inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; • metal ion binding; • GO:0001948 protein binding; • RNA binding; • inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; • hydrolase activity; • diphosphoinositol-polyphosphate diphosphatase activity; • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; • inositol diphosphate pentakisphosphate diphosphatase activity; • inositol bisdiphosphate tetrakisphosphate diphosphatase activity; • endopolyphosphatase activity; • bis(5'-adenosyl)-hexaphosphatase activity; • bis(5'-adenosyl)-pentaphosphatase activity; • m7G(5')pppN diphosphatase activity; • snoRNA binding;
Cellular component	• intracellular; • cell nucleus; • cytoplasm; • cytosol;
Biological process	• GO:0007243 intracellular signal transduction; • cyclic nucleotide metabolic process; • inositol phosphate metabolic process; • cyclic-nucleotide-mediated signaling; • calcium-mediated signaling; • diphosphoinositol polyphosphate metabolic process; • diadenosine pentaphosphate catabolic process; • diadenosine hexaphosphate catabolic process; • adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11163
	71207
	ENSG00000173598
	ENSMUSG00000020029
	Q9NZJ9
	Q8R2U6
	NM_001301022; NM_001301023; NM_001301024; NM_019094; NM_199040
	NM_027722; NM_001358996
	NP_001287951; NP_001287952; NP_001287953; NP_061967; NP_950241
	NP_081998; NP_001345925
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.[5][6][7]

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.[7]

References

GRCh38: Ensembl release 89: ENSG00000173598 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020029 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Caffrey JJ, Safrany ST, Yang X, Shears SB (Jun 2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family". J Biol Chem. 275 (17): 12730–6. doi:10.1074/jbc.275.17.12730. PMID 10777568.
Caffrey JJ, Shears SB (May 2001). "Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2". Gene. 269 (1–2): 53–60. doi:10.1016/S0378-1119(01)00446-2. PMID 11376937.
"Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi:10.1186/1471-2091-3-20. PMC 117780. PMID 12121577.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173598 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020029 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10777568-5] Caffrey JJ, Safrany ST, Yang X, Shears SB (Jun 2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family". J Biol Chem. 275 (17): 12730–6. doi:10.1074/jbc.275.17.12730. PMID 10777568.

[pmid11376937-6] Caffrey JJ, Shears SB (May 2001). "Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2". Gene. 269 (1–2): 53–60. doi:10.1016/S0378-1119(01)00446-2. PMID 11376937.

[entrez-7] "Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4".

NUDT4

References

Further reading