NUF2

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.[5][6][7]

NUF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUF2, CDCA1, CT106, NUF2R, NDC80 kinetochore complex component, NDC80 kinetochore complex component NUF2 component of NDC80 kinetochore complex
External IDsOMIM: 611772 MGI: 1914227 HomoloGene: 40205 GeneCards: NUF2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start163,266,576 bp[1]
End163,355,764 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

83540

66977

Ensembl

ENSG00000143228

ENSMUSG00000026683

UniProt

Q9BZD4

Q99P69

RefSeq (mRNA)

NM_031423
NM_145697

NM_023284
NM_001355159

RefSeq (protein)

NP_113611
NP_663735

NP_075773
NP_001342088

Location (UCSC)Chr 1: 163.27 – 163.36 MbChr 1: 169.5 – 169.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation.

The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000143228 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026683 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wigge PA, Kilmartin JV (Mar 2001). "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation". J Cell Biol. 152 (2): 349–60. doi:10.1083/jcb.152.2.349. PMC 2199619. PMID 11266451.
  6. Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y (Oct 2001). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID 11685532. S2CID 22443613.
  7. "Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading

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