Naltrexone/bupropion

Naltrexone/bupropion is indicated, as an adjunct to a reduced-calorie diet and increased physical activity, for the management of weight in adults with an initial Body Mass Index (BMI) of:[1][2]

• 30 kg/m² (obese), or[1][2]
• 27 kg/m² to < 30 kg/m², (overweight) in the presence of one or more weight-related comorbidities, like type 2 diabetes, dyslipidaemia, or controlled high blood pressure[1][2]

The manufacturer recommends against its use in people that have/are:[1]

• History of seizures
• History of an eating disorder such as bulimia nervosa or anorexia nervosa
• Taking opioid pain medicines, taking medicines to stop opioid addiction, or are in opiate withdrawal
• Taking an MAOI or have taken an MAOI in the last 14 days
• Pregnant
• Abruptly stopped using: alcohol, benzodiazepines, barbiturates, or antiepileptic drugs

The U.S. Food and Drug Administration (FDA) has put a boxed warning onto this medicine because it may affect mood and increase the likelihood of suicide.[1]

The safety and effectiveness in children under the age of 18 has not been studied.[1]

Individually, naltrexone and bupropion each target pathways in the central nervous system that influence appetite and energy use.

• Bupropion is a reuptake inhibitor and releasing agent of both norepinephrine and dopamine, and a nicotinic acetylcholine receptor antagonist, and it activates proopiomelanocortin (POMC) neurons in the hypothalamus which give an effect downstream, resulting in loss of appetite and increased energy output. The POMC is regulated by endogenous opioids via opioid-mediated negative feedback.
• Naltrexone is a pure opioid antagonist, which further augments bupropion's activation of the POMC.[8]

Combined, naltrexone/bupropion has an effect on the reward pathway that results in reduced food craving.[9] In 2009, Monash University physiologist Michael Cowley was awarded one of Australia's top research honors, the Commonwealth Science Minister's Prize for Life Scientist of the Year, in recognition of his elucidation of these pathways, which led to the development of the combination medication.[10]

Orexigen submitted a New Drug Application (NDA) for this drug combination to the U.S. Food and Drug Administration (FDA) on 31 March 2010.[11] Having paid a fee under the Prescription Drug User Fee Act, Orexigen was given a deadline for the FDA to approve or reject the drug of 31 January 2011. On 7 December 2010, an FDA Advisory Committee voted 13-7 for the approval of Contrave, and voted 11-8 for the conduct of a post-marketing cardiovascular outcomes study.[12] Subsequently, on 2 February 2011, the FDA rejected the drug and it was decided that an extremely large-scale study of the long-term cardiovascular effects of Contrave would be needed, before approval could be considered.[13] It was ultimately approved in the United States in the fall of 2014.[6]

In December 2014, the EU's Committee for Medicinal Products for Human Use (CHMP) endorsed the combination for licensure as an obesity medication when used alongside diet and exercise.[14] Approval was granted in late March 2015.[7]

In May 2015, Orexigen ended a safety study of its diet drug earlier than planned, because an independent panel of experts says the drug maker “inappropriately” compromised the trial by prematurely releasing interim data. The early data release reported a reduction in heart attacks that was no longer observed when a more complete view of the data was analyzed.[15]

In 2018, Orexigen sold its assets, including Contrave, to Nalpropion Pharmaceuticals.[16][17]

The sustained-release formulation, Contrave, is marketed by Takeda under license from the combination medication's developer, Orexigen Therapeutics.[6] As of 2015, Orexigen received 20% of net sales from Takeda.[18]

At the time of its approval by FDA, Wells Fargo analyst Matthew Andrews estimated that Contrave's U.S. sales would reach approximately US$200,000,000 in 2016, exceeding that of the dominant alternative obesity medications lorcaserin and phentermine/topiramate.[19] Despite being initially impeded by technical issues, the growth in filled prescriptions in the first months after approval was very rapid — substantially exceeding the equivalent early uptake of either of the two alternative medications just cited.[20] The first quarter of sales for Contrave (Q1 2015) showed net sales of US$11,500,000.[18]

Despite having been approved for use in Europe in March 2015, sales of Contrave have not begun as Orexigen has not yet found a marketing partner.[18]

• Bupropion/zonisamide
• Bupropion/dextromethorphan

• "Bupropion mixture with naltrexone". Drug Information Portal. U.S. National Library of Medicine.