Neuronal PAS domain protein 4

NPAS4
Identifiers
Aliases	NPAS4, Le-PAS, NXF, PASD10, bHLHe79, neuronal PAS domain protein 4
External IDs	OMIM: 608554 MGI: 2664186 HomoloGene: 15333 GeneCards: NPAS4
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	66,426,707 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	4,990,316 bp[2]
Gene ontology
Molecular function	• DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • protein dimerization activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948 protein binding; • protein heterodimerization activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• postsynapse; • transcription regulator complex; • cell nucleus;
Biological process	• positive regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • cellular response to corticosterone stimulus; • positive regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • transcription from RNA polymerase II promoter; • nervous system development; • learning; • short-term memory; • long-term memory; • cell differentiation; • regulation of synaptic transmission, GABAergic; • social organism behavior; • regulation of synaptic plasticity; • excitatory postsynaptic potential; • inhibitory postsynaptic potential; • inhibitory synapse assembly; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	266743
	225872
	ENSG00000174576
	ENSMUSG00000045903
	Q8IUM7
	Q8BGD7
	NM_178864; NM_001318804
	NM_153553
	NP_001305733; NP_849195
	NP_705781
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene.[5] The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.[6]

Function

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].

Npas4 has been shown by Dr. Brenda Bloodgood to play critical roles in regulating the plasticity of inhibitory neurons. She found that Npas4 helps to regulate plasticity by orchestrating a redistribution of synaptic inputs, biasing them towards dendrites over neuronal cell bodies which increases dendritic plasticity.[7]

References

GRCh38: Ensembl release 89: ENSG00000174576 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000045903 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Neuronal PAS domain protein 4". Retrieved 2017-10-15.
Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.
Bloodgood, Brenda L.; Sharma, Nikhil; Browne, Heidi Adlman; Trepman, Alissa Z.; Greenberg, Michael E. (2013-11-07). "The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition". Nature. 503 (7474): 121–125. doi:10.1038/nature12743. ISSN 1476-4687. PMC 4169177. PMID 24201284.

Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.
Bersten DC, Bruning JB, Peet DJ, Whitelaw ML (2014). "Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function". PLOS ONE. 9 (1): e85768. doi:10.1371/journal.pone.0085768. PMC 3894988. PMID 24465693.
Klaric TS, Thomas PQ, Dottori M, Leong WK, Koblar SA, Lewis MD (2014). "A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells". Stem Cell Res Ther. 5 (3): 64. doi:10.1186/scrt453. PMC 4076635. PMID 24887558.
Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174576 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045903 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Neuronal PAS domain protein 4". Retrieved 2017-10-15.

[6] Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.

[7] Bloodgood, Brenda L.; Sharma, Nikhil; Browne, Heidi Adlman; Trepman, Alissa Z.; Greenberg, Michael E. (2013-11-07). "The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition". Nature. 503 (7474): 121–125. doi:10.1038/nature12743. ISSN 1476-4687. PMC 4169177. PMID 24201284.

Neuronal PAS domain protein 4

Function

References

Further reading