Nicholas Weise

Nicholas J. Weise is a British chemist and a Lecturer in the Department of Chemistry at The University of Manchester.[1] His research in general is based on organic chemistry and molecular biology, specifically on enzymology, biocatalysis and industrial biotechnology.[7] He also engages in chemistry based public engagement projects within the University of Manchester.[8]

Nicholas Weise
Dr. Nicholas Weise
Born
Nicholas J. Weise
Alma materUniversity of Manchester[1] (Bsc., PhD)
Known forEnzymology
Biocatalysis
Industrial Biotechnology
Public Engagement
Awards
  • Better World Award (2020) [2]
  • Making a Difference Award, Highly Commended (2020,[3] 2019[4])
  • Making a Difference Award, Commended (2018,[5] 2017[6])
Scientific career
FieldsOrganic Chemistry
Molecular Biology
InstitutionsThe University of Manchester
ThesisDiscovery and Development of Class I Lyase-like Enzymes for Biotechnological Applications (2016)
Doctoral advisorProf. Nicholas Turner
Prof. Sabine Flitsch

Education

Weise completed his Bachelor of Science in Molecular Biology in 2012 at University of Manchester.[1] He then continued to read for his Doctor of Philosophy degree on Discovery and Development of Class I Lyase-like Enzymes for Biotechnological Applications and successfully completed it in 2016.[9] His PhD was supervised by Prof. Nicholas Turner and Prof. Sabine Flitsch.[9]

Research and career

Upon graduation, Weise worked as a Postdoctoral researcher from 2015 - 2017 at the Manchester Institute of Biotechnology and during this time, he also worked as a Visiting Fellow from 2016 - 2017 at Open University.[1] He was later promoted to the position of Lecturer at University of Manchester and was also awarded a Senior Fellowship in the Higher Education Academy and is the current Chemistry PASS managing staff at University of Manchester.[1][10][11]

Weise's research in general is based on organic chemistry and molecular biology, specifically on enzymology, biocatalysis and industrial biotechnology.[7] He also engages in chemistry based public engagement projects within the University of Manchester.[8]

Notable work

Weise's work in general is based on industrial biotechnology including the enzyme Phenylalanine Ammonia Lyases (PALs). In 2018, Weise participated in a research along with Prof.Nicholas Turner and Prof. Nigel Scrutton in which via the combination of three biocatalyst classes (phenylalanine ammonia lyase, carboxylic acid reductase and alcohol dehydrogenase), cinnamyl alcohol could be obtained from the primary metabolite and the fermentation product L-phenylalanine.[12] This was the first reported process in which cinnamyl alcohol could be produced without being dependent on petrochemical starting materials.[12]

Weise has also participated in several outreach and Public Engagement activities and is the current Head of Social Responsibility and the Teaching & Learning Enhancement Lead in the Department of Chemistry at University of Manchester.[13][14][15] Working with Multilingual Manchester, Weise carried out and developed the first Multilingual Science Workshops in Manchester, where the promotion of science with language diversity was achieved.[16] The activities were carried out at Al-Manar Arabic School, Burnage and Hellenic School of Manchester, Salford.[16]

Awards and Nominations
  • Better World Award (2020) [2]
  • Making a Difference Award, Highly Commended (2020,[3] 2019[4])
  • Making a Difference Award, Commended (2018,[5] 2017[6])

Major Publications
  • Weise, Nicholas; Klumbys, Evaldas; Zebec, Ziga; Turner, Nicholas J.; Scrutton, Nigel S. (2018). "Bio-derived production of cinnamyl alcohol via a three step biocatalytic cascade and metabolic engineering". Green Chemistry. 20 (3): 658–663. doi:10.1039/C7GC03325G. PMC 6546598. PMID 31168294.
  • Weise, Nicholas J.; Ahmed, Syed T.; Parmeggiani, Fabio; Turner, Nicholas J. (2017). "Kinetic Resolution of Aromatic β‐Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts". Adv. Synth. Catal. 359 (9): 1570. doi:10.1002/adsc.201600894. hdl:11311/1126551.
  • Weise, Nicholas J.; Wood, Alexander J. L.; Frampton, Joseph D.; Dunstan, Mark S.; Hollas, Michael A.; Derrington, Sasha R.; Lloyd, Richard C.; Quaglia, Daniela; Parmeggiani, Fabio; Leys, David; Turner, Nicholas J.; Flitsch, Sabine L. (2017). "Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides". Angewandte Chemie International Edition. 56 (46): 14498–14501. doi:10.1002/anie.201707918. hdl:11311/1126305. PMID 28940631.
  • Weise, Nicholas J.; Ahmed, Syed T.; Parmeggiani, Fabio; Siirola, Elina; Pushpanath, Ahir; Schell, Ursula; Turner, Nicholas J. (2016). "Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source". Catalysis Science and Technology. 6 (12): 4086–4089. doi:10.1039/C6CY00855K.
  • Weise, Nicholas J.; Ahmed, Syed T.; Parmeggiani, Fabio; Flitsch, Sabine L.; Turner, Nicholas J. (2018). "Synthesis of Enantiomerically Pure Ring-Substituted l-Pyridylalanines by Biocatalytic Hydroamination". Organic Letters. 18 (21): 5468–5471. doi:10.1021/acs.orglett.6b02559. PMID 27768317.

References
  1. University of Manchester. "Dr. Nicholas Weise". Retrieved 18 June 2020.
  2. University of Manchester. "Better World Awards (2020)". Retrieved 18 June 2020.
  3. University of Manchester. "2020 Making a Difference Awards". Retrieved 18 June 2020.
  4. University of Manchester. "2019 Making a Difference Awards". Retrieved 18 June 2020.
  5. University of Manchester. "2018 Making a Difference Awards". Retrieved 18 June 2020.
  6. University of Manchester. "2017 Making a Difference Awards". Retrieved 18 June 2020.
  7. "Nicholas Weise (Publications)". Retrieved 18 June 2020.
  8. "Public Engagement (2018)". Retrieved 18 June 2020.
  9. Nicholas, Weise (2016). Discovery and Development of Class I Lyase-like Enzymes for Biotechnological Applications (PDF) (PhD thesis).
  10. Chemistry PASS (University of Manchester). "Management Team of Chemistry PASS". Retrieved 18 June 2020.
  11. "Current Management Board of Chemistry Department (University of Manchester)". Retrieved 18 June 2020.
  12. Weise, Nicholas; Klumbys, Evaldas; Zebec, Ziga; Turner, Nicholas J.; Scrutton, Nigel S. (2018). "Bio-derived production of cinnamyl alcohol via a three step biocatalytic cascade and metabolic engineering". Green Chemistry. 20 (3): 658–663. doi:10.1039/C7GC03325G. PMC 6546598. PMID 31168294.
  13. "Chemistry: Late at the Science and Industry Museum". Retrieved 18 June 2020.
  14. University of Manchester. "Community Festival 2019". Retrieved 18 June 2020.
  15. "Multilingual Community Visit (Polish School, Chorlton)". Retrieved 18 June 2020.
  16. Royal Society of Chemistry (14 July 2017). "Science outreach goes multilingual". Manchester, United Kingdom. Retrieved 18 June 2020.
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