Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.[5][6]

NUMA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUMA1, NUMA, NMP-22, nuclear mitotic apparatus protein 1
External IDsOMIM: 164009 MGI: 2443665 HomoloGene: 38150 GeneCards: NUMA1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.4Start72,002,864 bp[1]
End72,080,693 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4926

101706

Ensembl

ENSG00000137497

ENSMUSG00000066306

UniProt

Q14980
Q3SYK8

E9Q7G0

RefSeq (mRNA)

NM_001286561
NM_006185

NM_133947

RefSeq (protein)

NP_001273490
NP_006176
NP_006176.2

NP_598708

Location (UCSC)Chr 11: 72 – 72.08 MbChr 7: 101.93 – 102.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1,[7] Band 4.1,[8] GPSM2[9] and EPB41L1.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000137497 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000066306 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sparks CA, Bangs PL, McNeil GP, Lawrence JB, Fey EG (Oct 1993). "Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13". Genomics. 17 (1): 222–224. doi:10.1006/geno.1993.1307. PMID 8406455.
  6. "Entrez Gene: NUMA1 nuclear mitotic apparatus protein 1".
  7. Bhattacharya, Nandini; Wang Zeping; Davitt Christine; McKenzie Ian F C; Xing Pei-Xiang; Magnuson Nancy S (Jul 2002). "Pim-1 associates with protein complexes necessary for mitosis". Chromosoma. Germany. 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. ISSN 0009-5915. PMID 12111331. S2CID 26016943.
  8. Mattagajasingh, S N; Huang S C; Hartenstein J S; Snyder M; Marchesi V T; Benz E J (Apr 1999). "A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein". J. Cell Biol. UNITED STATES. 145 (1): 29–43. doi:10.1083/jcb.145.1.29. ISSN 0021-9525. PMC 2148212. PMID 10189366.
  9. Du, Q; Stukenberg P T; Macara I G (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. England. 3 (12): 1069–1075. doi:10.1038/ncb1201-1069. ISSN 1465-7392. PMID 11781568. S2CID 7955950.
  10. Ye, K; Compton D A; Lai M M; Walensky L D; Snyder S H (Dec 1999). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. UNITED STATES. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q14980 (Nuclear mitotic apparatus protein 1) at the PDBe-KB.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.