Nuru Bayramov

Nuru Bayramov's scientific career has started from student days. He has been a member of the Student Scientific Community from the 3rd year of the university, the chairman of the Student Scientific Society of the Faculty of Treatment and Prevention between 1984–1986, and has repeatedly spoken at conferences of Student Scientific Societies in Azerbaijan and various countries of the USSR. While he was a student, he published 11 scientific papers. Given his excellent studentship and active involvement in research, he was awarded the Lenin Scholarship, the highest scholarship of the Institute in 1985. He continued his scientific activity during clinical internship and received patent certificate for the new treatment of Pilonidal sinus disease.

His later research activity continued between 1988-1991 as a postgraduate study in Department of General Surgery in I.M. Sechenov First Moscow State Medical University. He has done scientific work on the use of lasers in surgery under the guidance of professors V.I. Gostishev and V.A. Vertyanov.

Between 1991-1994 he continued research of the use of lasers and the water-soluble based ointments for treatment of gunshot and cold injuries in Azerbaijan Medical University. Results of this studies were published in some articles and doctoral thesis.

His next research activity continued in 1994–2000 at the Advanced Specialty Hospital of Turkey, Başkent University, Ankara University and Van Yüzüncü Yıl University. In addition to being specialized in these education and research centers, he has performed clinical and experimental studies on transplantation, liver resection and laparoscopic surgery. Liver resection in live donors, water-jet for liver resection, CUSA) and argon coagulation in the cirrhotic liver resection, effects of lasers and dalargin on liver regeneration, liver regeneration after resection, prevention of postresection complications, complication after laparoscopic surgery, classification of the gunshot injuries of the liver have been his main research topics of this period. He conducted an experimental study on the use of waterjet in liver resection at the Van Yüzüncü Yıl University in 1997 and was able to specify some parameters of the water jet (diameter and pressure). Several articles and one doctoral thesis on this topic are defended.

As a result of clinical and experimental studies on liver resection and transplantation he has published 2 monographs and 31 articles. In 1999 he defended his thesis on "Prediction and prevention of complications after liver resection" and received a scientific degree of "Doktor Nauk in Medical Sciences".

Back in 2000, Nuru Bayramov returned to Azerbaijan, where he previously worked as an associate professor at the Azerbaijan Medical University, and currently head of the Department of I Surgical Diseases. The main areas of his research during this period are liver resection, liver and kidney transplantation, laparoscopic and metabolic surgery, stem cells and genetic studies. Under his leadership doctoral thesis on topics of laparoscopic appendectomy, laparoscopic fundoplication, laparoscopic bile duct exploration, laparoscopic hernia repair, simultaneuse laproscopic surgery were defended. At present doctoral thesis on topics such as biliary complications, microRNA, histones and hepatic dysfunctions after liver transplantation, iodine polymers in thyroid pathology, elastography in liver pathology, bariatric surgery in obesity are continued. Grant projects on gene polymorphism in cirrhosis, elastography and fatty liver have been adopted. For the first time in Azerbaijan, it was used by stem cells for liver disease.

He has been active in scientific and organizational work in Azerbaijan and around the world. In Azerbaijan he actively participated in defining and promoting pillar priorities of medical science (stem cells and regenerative medicine, genomics, molecular biology, high technologies and medicine, evidence-based medicine, translational medicine, etc.). He has been organizing 5-6 international conferences every year since 2014, including Baku-Malatya Transplant Days, Turkey-Azerbaijan Hepatology Course, Regular Conferences on Bariatric Surgery, Endocrine Surgery, Colorectal Surgery.

Up to date (2019), he had participated in 193 congresses, a total of 345 scientific works was published: 25 books, 9 methodical recommendations, 125 articles, 186 congress abstracts and 10 inventions and effective proposals.

Under his supervision 5 scientific dissertations were defended. He is a participant of two grant projects.

Nuru Bayramov has actively involved in the process of modernization and development of clinical, scientific medicine and medical education in Azerbaijan. In the 1990s, he involved in advanced care of victims in the first Karabakh War and in frontline military hospitals. He has taken active part in the treatment of civilians who forced to leave their homes in the Khojaly Massacre in 1992 and had frostbite in their hands and feet and had successfully implemented a new method of treatment. In January 1994, he worked at the Military Desert Hospital No. 2 in Tartar region and treated of numerous wounded soldiers.

He has been active in the organization of general, laparoscopic and liver surgery at Van Yüzüncü Yıl University and Kırıkkale University.

He has been pioneering in the development and implementation of international clinical protocols, laying the foundations of laparoscopic, transplantation, liver and bariatric-metabolic surgery in Azerbaijan.

He has actively participated in establishment of laparoscopyc, transplantation centers and realization of the liver and kidney transplantation in prime hospitals in Azerbaijan such as, Central Clinic Hospital, M. Naghiyev Emergency and Medical Care Hospital, Central Customs Hospital and Azerbaijan Medical University Surgical Educational Hospital.

He has broken grounds in healthcare industry in Azerbaijan by leading first stem cell transplantation, major liver resections, hepatectomy including (ALPPS) surgery, damage control surgery, laparostomy and mesh closure surgery, advanced laparoscopic operations such as, common bile duct exploration and resection, choledocho-duodenostomy, choledocho-yeyunostomy, fundoplication, liver, pancreas, gastric, bowel, colon resections, portal vein ligations, gasto-yeyunostomy, splenectomy, hysterectomy, cystectomy, renal operations and sympathectomy, thoracoscopic phrenic nervectomy (first time in the world) and first organ transplantation in Azerbaijan Medical University (2015).

His initiate surgeons have an important role in the development and wide application of laparoscopic surgery in Azerbaijan and around the world.

Nuru Bayramov was a participant and international expert at “Live transplantation for 5 patients at the same time” held at Inonu University's Liver Transplantation Institute (Malatya, Turkey) which was awarded and granted by Guinness World Records Title.[2]

Nuru Bayramov started his pedagogical activities at General Surgery Department in I.M. Sechenov First Moscow State Medical University the continued in Azerbaijan Medical University (1991-1994), Van Yüzüncü Yıl University (1996-1997), Kırıkkale University (1998) and Azerbaijan Medical University from 1999 until today. Currently he is head of 1st Department of Surgical Diseases.

He was also actively involved in modernizing the surgical education of students and residents in Azerbaijan. Under his leadership, a modern educational program for students and residents has been developed for the first time in our country. Including a curriculum for Surgical Diseases and Military Surgery, an online surgical textbook, and an online portal named bck.az, compiled electronic versions of teaching materials, including lectures, practical topics, operating techniques and test questions, started using multimedia tools, organized interactive morning lessons and concerts, developed surgical patient examination and treatment protocols, open to students and residents. laparoscopic surgical training courses, courses abroad and online.

• It has been found that there are two principles of the effect of blood red laser irradiation on the immune system: the stimulated immune system is suppressed, and the suppressed system is stimulates; This effect reaches a maximum of 3–4 days and disappears after 7 days. Based on this, a method of prediction has been developed (1990).
• Laser radiation of blood has a corrective effect on the coagulation system and has a positive effect on liver regeneration (1990).
• Water-soluble based ointments and red laser irradiation of intravascular blood are useful for early management of frostbite (1992).

• In cirrhotic liver resections combined application of CUSA (Cavitron Ultrasonic Surgical Aspirator) and argon beam coagulator is more useful than alone (1996).
• Parameters (diameter and pressure) of water-jet for liver resection have been specified (1997).
• The dynamics of post-resection regeneration of normal and cirrhotic liver have been identified (1996).
• The regeneration stimulators have little effect on normal liver regeneration, but it is needed for cirrhotic and hepatitis livers and for this purpose the blood laser irradiation may be useful (1996).
• Intraoperative indocyanine green test is useful for prediction of posthepatectomy liver failure. (1996).
• Experimental models of liver cysts and abscesses have been developed (1996).

• The most common complications in the living liver donors are the biliary complications, most of which are mild degree (2012).
• Biliary complications in live liver transplantation represent a serious problem (up to 30%), and anti-ischemic and distal transanastomotic drainage procedures are useful in surgical prophylaxis (2012).
• Liver transplantation may be the first choice in patients with hepatocellular carcinoma and cirrhosis (2010).
• Liver transplantation is possible in some diseases of the liver (portal vein thrombosis, vascular alveolar echinococcosis) (2014).
• Electron microscopy discovered advanced fat in hepatocytes of liver donors, who was seemed normal on standard clinical, laboratory and imaging studies. The clinical significance of this result should be explored in future studies (2015).

• Wide dissection of the Calot's triangle and adherence to the “two-window” principle with artery ligation first significantly decreases complications and may be referred as standard technique for laparoscopic cholecystectomy (1997).
• Early (within 24 hours) laparoscopic surgery in acute cholecystitis is more effective, even in patients with cirrhosis (1998).
• Endoscopic stend and drainage are effective first-step options for partial biliary duct injury (1999).
• In patients with cholecysto-choledocholithiasis one-stage laparoscopic common bile duct exploration and cholecystectomy has surgical and economical advantage over two-stage approach. (2003)
• Laparoscopic approach decrease complications and hospital stay in both complicated and uncomplicated appendectomies. (2003)
• Simultaneous laparoscopic operations of two or more surgical pathologies in the abdominal cavity reduces overall complications and does not increase specific complications (2004).
• Laparoscopic approach is first choice for treatment of hydatid cysts irrespective of number, complication and location, and the intaoperative ultrasound facilitates this work (2004).
• Laparoscopic hernioplasty significantly decreases wound complication rate and may refer as first choice for treatment of postoperative abdominal hernias. (2002)
• Laparoscopic fundoplication reduce recurrence of Barret's esophagus and may reverse metaplasia (2006).

• Preliminary results have shown that autologous bone marrow derived mesenchymal stem cell transplantation directly into the liver is a reliable method, which can correct coagulopathy in severe cirrhosis (2015).
• Studies of stem cells in colon polyps have shown that the number of stem cells (CD133 positive) in villous adenomas is greater than that of others and has higher potential for malignancy (2017).

• Preliminary analysis of elastographic examinations shows that the splenic stiffness correlated with degree of portal hypertension and varicose vein. Based on this result, the splenic elastography may be used as a non-invasive test for assessment the severity of portal hypertension and bleeding risk (2017).
• The results of elastographic study of liver transplant patients show that after transplantation the stiffness of spleen has gradually reduced irrespective of complications, whereas stiffness of liver graft was stable in patients without complications, but increase in complicated cases. According to these preliminary results, graft elastography may be a useful tool for assessing and monitoring of post-transplant liver dysfunction and portal hypertension (2018).

European Association for the Study of the Liver (EASL), European Association for Endoscopic Surgery (EAES), European Society for Organ Transplantation (ESOT), European Society for Colorectal Surgeons (ESCS), International Liver Transplant Society (ILTS), The Transplantation Society (TTS), International Association of Surgeons, Gastroenterologists, and Oncologists (IASGO), The International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), European Transluminal Surgery Society (EATS), Asian and Passific Association for the Study of the Liver (APASL), Clinical Robotic Surgery Association (CRSA) and Society of Gastroenterologists in Turkey.