OTUB1

Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene.[3][4] Alternative splicing results in multiple transcript variants.

OTUB1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesOTUB1, OTB1, OTU1, HSPC263, OTU deubiquitinase, ubiquitin aldehyde binding 1
External IDsOMIM: 608337 HomoloGene: 134542 GeneCards: OTUB1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start63,985,853 bp[1]
End64,001,811 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55611

n/a

Ensembl

ENSG00000167770

n/a

UniProt

Q96FW1

n/a

RefSeq (mRNA)

NM_017670

n/a

RefSeq (protein)

NP_060140

n/a

Location (UCSC)Chr 11: 63.99 – 64 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Otubain-1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains, being specific for lysine48 -linked polyubiquitin but not lysine63 -linked polyubiquitin.[5] It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth.[4]

Interactions

OTUB1 has been shown to interact with RNF128[6] and GNB2L1.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000167770 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
  4. "Entrez Gene: OTUB1 OTU domain, ubiquitin aldehyde binding 1".
  5. Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM (March 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination". Biochem. J. 418 (2): 379–90. doi:10.1042/BJ20081318. PMID 18954305.
  6. Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG (January 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020. S2CID 27005972.

Further reading


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