PAIP1

Polyadenylate-binding protein-interacting protein 1 is a protein that in humans is encoded by the PAIP1 gene.[5][6][7]

PAIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAIP1, poly(A) binding protein interacting protein 1
External IDsOMIM: 605184 MGI: 2384993 HomoloGene: 4709 GeneCards: PAIP1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p12Start43,526,267 bp[1]
End43,557,758 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10605

218693

Ensembl

ENSG00000172239

ENSMUSG00000025451

UniProt

Q9H074

Q8VE62

RefSeq (mRNA)

NM_006451
NM_182789
NM_183323

NM_001079849
NM_145457

RefSeq (protein)

NP_006442
NP_877590
NP_899152

NP_001073318
NP_663432

Location (UCSC)Chr 5: 43.53 – 43.56 MbChr 13: 119.43 – 119.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[7]

Interactions

PAIP1 has been shown to interact with PABPC1.[5][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000172239 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025451 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Craig AW, Haghighat A, Yu AT, Sonenberg N (Apr 1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature. 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260. S2CID 10891925.
  6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. "Entrez Gene: PAIP1 poly(A) binding protein interacting protein 1".
  8. Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N (Jun 2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs". Mol. Cell. Biol. 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. PMC 133836. PMID 11997512.

Further reading


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