PCOLCE

Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene.[5][6][7]

PCOLCE
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCOLCE, PCPE, PCPE-1, PCPE1, procollagen C-endopeptidase enhancer
External IDsOMIM: 600270 MGI: 105099 HomoloGene: 1946 GeneCards: PCOLCE
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start100,602,363 bp[1]
End100,608,175 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5118

18542

Ensembl

ENSG00000106333

ENSMUSG00000029718

UniProt

Q15113

Q61398

RefSeq (mRNA)

NM_002593

NM_008788

RefSeq (protein)

NP_002584

NP_032814

Location (UCSC)Chr 7: 100.6 – 100.61 MbChr 5: 137.61 – 137.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens activity.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000106333 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029718 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics. 31 (2): 253–256. doi:10.1006/geno.1996.0043. PMID 8824813.
  6. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–1073. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
  7. "Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer".

Further reading

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