PDCD6IP

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.[5][6]

PDCD6IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDCD6IP, AIP1, ALIX, DRIP4, HP95, programmed cell death 6 interacting protein
External IDsOMIM: 608074 MGI: 1333753 HomoloGene: 22614 GeneCards: PDCD6IP
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p22.3Start33,798,571 bp[1]
End33,869,707 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10015

18571

Ensembl

ENSG00000170248

ENSMUSG00000032504

UniProt

Q8WUM4

Q9WU78

RefSeq (mRNA)

NM_001162429
NM_001256192
NM_013374

NM_001164677
NM_001164678
NM_011052

RefSeq (protein)

NP_001155901
NP_001243121
NP_037506

NP_001158149
NP_001158150
NP_035182

Location (UCSC)Chr 3: 33.8 – 33.87 MbChr 9: 113.65 – 113.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.[6]

Function

PDCD6IP protein is part of ESCRT pathway. It participates in the membrane scission of the revers topology budding and participates in multivesicular body formation.[7] It is also vital at the later stages and for successful completion of cytokinesis.[8]

Interactions

PDCD6IP has been shown to interact with PDCD6.[5][9] The V domain of PDCD6IP recognises Short linear motif LYPxLxxL and this motif is mimicked by p6 late domain of HIV and related viruses which facilitates viral hijacking of ESCRT pathway and consequential budding of viral particles.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000170248 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032504 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vito P, Pellegrini L, Guiet C, D'Adamio L (Feb 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J Biol Chem. 274 (3): 1533–40. doi:10.1074/jbc.274.3.1533. PMID 9880530.
  6. "Entrez Gene: PDCD6IP programmed cell death 6 interacting protein".
  7. Vietri, Marina; Radulovic, Maja; Stenmark, Harald (January 2020). "The many functions of ESCRTs". Nature Reviews Molecular Cell Biology. 21 (1): 25–42. doi:10.1038/s41580-019-0177-4. PMID 31705132. S2CID 207939465.
  8. Carlton, Jez G.; Martin-Serrano, Juan (29 June 2007). "Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery". Science. 316 (5833): 1908–1912. Bibcode:2007Sci...316.1908C. doi:10.1126/science.1143422. PMID 17556548. S2CID 29191843.
  9. Satoh, Hirokazu; Shibata Hideki; Nakano Yoshimi; Kitaura Yasuyuki; Maki Masatoshi (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochem. Biophys. Res. Commun. United States. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. ISSN 0006-291X. PMID 11883939.
  10. Votteler, Jörg; Sundquist, Wesley I. (September 2013). "Virus Budding and the ESCRT Pathway". Cell Host & Microbe. 14 (3): 232–241. doi:10.1016/j.chom.2013.08.012. PMC 3819203. PMID 24034610.

Further reading

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