PFDN5

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.[4][5][6]

PFDN5
Identifiers
AliasesPFDN5, MM-1, MM1, PFD5, prefoldin subunit 5
External IDsOMIM: 604899 MGI: 1928753 HomoloGene: 1972 GeneCards: PFDN5
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.13Start53,295,291 bp[1]
End53,299,450 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5204

56612

Ensembl

ENSG00000123349

ENSMUSG00000001289

UniProt

Q99471

Q9WU28

RefSeq (mRNA)

NM_145897
NM_002624
NM_145896

NM_020031
NM_027044

RefSeq (protein)

NP_002615
NP_665904

NP_081320

Location (UCSC)Chr 12: 53.3 – 53.3 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

Interactions

PFDN5 has been shown to interact with Myc.[5][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000123349 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (May 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
  5. Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H (November 1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc". The Journal of Biological Chemistry. 273 (45): 29794–800. doi:10.1074/jbc.273.45.29794. PMID 9792694.
  6. "Entrez Gene: PFDN5 prefoldin subunit 5".
  7. Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H (November 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". The Journal of Biological Chemistry. 276 (48): 45137–44. doi:10.1074/jbc.M106127200. PMID 11567024.

Further reading


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