PHACTR3

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[6]

Interactions

PHACTR3 has been shown to interact with PPP1CA.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000087495 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027525 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
  6. "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
  7. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.