PIR (gene)

Pirin is a protein that in humans is encoded by the PIR gene.[5][6]

PIR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIR, pirin
External IDsOMIM: 300931 MGI: 1916906 HomoloGene: 2717 GeneCards: PIR
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp22.2Start15,384,799 bp[1]
End15,493,564 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8544

69656

Ensembl

ENSG00000087842

ENSMUSG00000031379

UniProt

O00625

Q9D711

RefSeq (mRNA)

NM_003662
NM_001018109

NM_001301402
NM_027153

RefSeq (protein)

NP_001018119
NP_003653

NP_001288331
NP_081429

Location (UCSC)Chr X: 15.38 – 15.49 MbChr X: 164.27 – 164.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[6]

Interactions

PIR (gene) has been shown to interact with BCL3.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000087842 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031379 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
  6. "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
  7. Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.

Further reading


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