PJA1

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.[5][6]

PJA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1
External IDsOMIM: 300420 MGI: 1101765 HomoloGene: 129620 GeneCards: PJA1
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq13.1Start69,160,851 bp[1]
End69,165,793 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64219

18744

Ensembl

ENSG00000181191

ENSMUSG00000034403

UniProt

Q8NG27

O55176

RefSeq (mRNA)

NM_001032396
NM_022368
NM_145119
NM_001382775
NM_001382776

NM_001083110
NM_001290555
NM_001290556
NM_008853

RefSeq (protein)

NP_001027568
NP_071763
NP_660095
NP_001369704
NP_001369705

NP_001076579
NP_001277484
NP_001277485
NP_032879

Location (UCSC)Chr X: 69.16 – 69.17 MbChr X: 99.47 – 99.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PJA1 has been shown to interact with UBE2D2[5] and MAGED1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000181191 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034403 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
  6. "Entrez Gene: PJA1 praja 1".
  7. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Further reading


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