PJA1

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.[5][6]

PJA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L0B

Identifiers

PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1

External IDs

OMIM: 300420 MGI: 1101765 HomoloGene: 129620 GeneCards: PJA1

Gene location (Human)

Chr.	X chromosome (human)[1]

Band	Xq13.1	Start	69,160,851 bp[1]
Band	Xq13.1	End	69,165,793 bp[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)[2]

Band	X C3\|X 43.38 cM	Start	99,465,734 bp[2]
Band	X C3\|X 43.38 cM	End	99,471,273 bp[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• GO:0001948 protein binding • metal ion binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transferase activity
Cellular component	• cytoplasm
Biological process	• protein catabolic process • protein ubiquitination
Sources:Amigo / QuickGO

Species

Human

Mouse


64219


18744


ENSG00000181191


ENSMUSG00000034403


Q8NG27


O55176

RefSeq (mRNA)


NM_001032396 NM_022368 NM_145119 NM_001382775 NM_001382776


NM_001083110 NM_001290555 NM_001290556 NM_008853

RefSeq (protein)


NP_001027568 NP_071763 NP_660095 NP_001369704 NP_001369705


NP_001076579 NP_001277484 NP_001277485 NP_032879

Location (UCSC)

Chr X: 69.16 – 69.17 Mb

Chr X: 99.47 – 99.47 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Interactions

PJA1 has been shown to interact with UBE2D2[5] and MAGED1.[7]

References

GRCh38: Ensembl release 89: ENSG00000181191 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034403 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
"Entrez Gene: PJA1 praja 1".
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Further reading

Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, et al. (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". The Journal of Biological Chemistry. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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