PLSCR1

Phospholipid scramblase 1 is an enzyme that in humans is encoded by the PLSCR1 gene.[5][6]

PLSCR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLSCR1, MMTRA1B, phospholipid scramblase 1
External IDsOMIM: 604170 MGI: 893575 HomoloGene: 41418 GeneCards: PLSCR1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q24Start146,515,180 bp[1]
End146,544,856 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5359

22038

Ensembl

ENSG00000188313

ENSMUSG00000032369

UniProt

O15162

Q9JJ00

RefSeq (mRNA)

NM_021105
NM_001363872
NM_001363874

NM_011636

RefSeq (protein)

NP_066928
NP_001350801
NP_001350803

NP_035766

Location (UCSC)Chr 3: 146.52 – 146.54 MbChr 9: 92.25 – 92.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PLSCR1 has been shown to interact with:

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000188313 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032369 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ (August 1997). "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids". J Biol Chem. 272 (29): 18240–4. doi:10.1074/jbc.272.29.18240. PMID 9218461.
  6. "Entrez Gene: PLSCR1 phospholipid scramblase 1".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (May 2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. doi:10.1021/bi025610l. PMID 12009895.
  9. Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (September 2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. doi:10.1074/jbc.M306182200. PMID 12871937.
  10. Tseng CC, Tseng CP (June 2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. doi:10.1016/s0014-5793(00)01700-2. PMID 10869562. S2CID 35688498.

Further reading


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