PLXNB1

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.[5][6][7]

PLXNB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
External IDsOMIM: 601053 MGI: 2154238 HomoloGene: 130508 GeneCards: PLXNB1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.31Start48,403,854 bp[1]
End48,430,086 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5364

235611

Ensembl

ENSG00000164050

ENSMUSG00000053646

UniProt

O43157

Q8CJH3

RefSeq (mRNA)

NM_001130082
NM_002673

NM_172775

RefSeq (protein)

NP_001123554
NP_002664

NP_766363

Location (UCSC)Chr 3: 48.4 – 48.43 MbChr 9: 109.1 – 109.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.[8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.[9]

Interactions

PLXNB1 has been shown to interact with ARHGEF12,[10] Rnd1[11] and ARHGEF11.[10][11][12][13]

References

  1. GRCh38: Ensembl release 89: ENSG00000164050 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053646 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
  6. Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A. 97 (23): 12457–62. Bibcode:2000PNAS...9712457V. doi:10.1073/pnas.220421797. PMC 18785. PMID 11035813.
  7. "Entrez Gene: PLXNB1 plexin B1".
  8. Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Letters. 529 (2–3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594. S2CID 26525009.
  9. Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway". Molecular and Cellular Biology. 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
  10. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
  11. Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  12. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  13. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. S2CID 18981429.
  • Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87; DOI: https://doi.org/10.4049/immunohorizons.1800026}}

Further reading

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