PLXND1

PLXND1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3H6N
Identifiers
Aliases	PLXND1, PLEXD1, plexin D1
External IDs	OMIM: 604282 MGI: 2154244 HomoloGene: 22866 GeneCards: PLXND1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	129,606,818 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	115,995,005 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein domain specific binding; • GO:0001948 protein binding; • semaphorin receptor activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • lamellipodium; • integral component of plasma membrane; • lamellipodium membrane; • cell projection; • semaphorin receptor complex;
Biological process	• cardiac septum development; • outflow tract morphogenesis; • regulation of angiogenesis; • coronary vasculature development; • multicellular organism development; • aorta development; • angiogenesis; • dichotomous subdivision of terminal units involved in salivary gland branching; • branching involved in blood vessel morphogenesis; • synapse assembly; • positive regulation of protein binding; • endothelial cell migration; • semaphorin-plexin signaling pathway; • signal transduction; • negative regulation of cell adhesion; • regulation of cell shape; • regulation of cell migration; • positive regulation of axonogenesis; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of transcription of Notch receptor target; • semaphorin-plexin signaling pathway involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	23129
	67784
	ENSG00000004399
	ENSMUSG00000030123
	Q9Y4D7
	Q3UH93
	NM_015103
	NM_026376
	NP_055918
	NP_080652
	Wikidata
View/Edit Human	View/Edit Mouse

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000004399 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030123 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H (Nov 2002). "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis". Dev Dyn. 225 (3): 336–43. doi:10.1002/dvdy.10159. PMID 12412018. S2CID 36110289.
"Entrez Gene: PLXND1 plexin D1".

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gitler AD, Lu MM, Epstein JA (2004). "PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development". Dev. Cell. 7 (1): 107–16. doi:10.1016/j.devcel.2004.06.002. PMID 15239958.
van der Zwaag B, Verzijl HT, Wichers KH, et al. (2004). "Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients". Pediatr. Neurol. 31 (2): 114–8. doi:10.1016/j.pediatrneurol.2004.02.004. PMID 15301830.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000004399 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030123 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12412018-5] van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H (Nov 2002). "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis". Dev Dyn. 225 (3): 336–43. doi:10.1002/dvdy.10159. PMID 12412018. S2CID 36110289.

[entrez-6] "Entrez Gene: PLXND1 plexin D1".

PLXND1

References

Further reading