POLR2G

POLR2G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C35, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G
External IDs	OMIM: 602013 MGI: 1914960 HomoloGene: 2019 GeneCards: POLR2G
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	62,766,710 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	8,798,577 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA-directed 5'-3' RNA polymerase activity; • single-stranded DNA binding; • single-stranded RNA binding; • RNA binding; • nucleic acid binding; • translation initiation factor binding;
Cellular component	• P-body; • nucleoplasm; • DNA-directed RNA polymerase II, core complex; • cell nucleus;
Biological process	• mRNA splicing, via spliceosome; • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; • transcription elongation from RNA polymerase II promoter; • 7-methylguanosine mRNA capping; • transcription from RNA polymerase II promoter; • transcription-coupled nucleotide-excision repair; • transcription initiation from RNA polymerase II promoter; • positive regulation of translational initiation; • nuclear-transcribed mRNA catabolic process, exonucleolytic; • apoptotic process; • snRNA transcription from RNA polymerase II promoter; • fibroblast growth factor receptor signaling pathway; • RNA metabolic process; • regulation of gene silencing by miRNA; • transcription, DNA-templated; • somatic stem cell population maintenance; • positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5436
	67710
	ENSG00000168002
	ENSMUSG00000071662
	P62487
	P62488
	NM_002696
	NM_026329
	NP_002687
	NP_080605
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.[5][6]

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.[7]

Interactions

POLR2G has been shown to interact with TAF15,[8] POLR2C,[9] POLR2H[9] and POLR2E.[9]

References

GRCh38: Ensembl release 89: ENSG00000168002 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000071662 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell. 6 (7): 759–75. doi:10.1091/mbc.6.7.759. PMC 301239. PMID 7579693.
Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta. 1353 (1): 39–49. doi:10.1016/s0167-4781(97)00041-9. PMID 9256063.
"Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G".
Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. UNITED STATES. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863. PMID 9488465.
Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359.
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099. S2CID 4233742.
Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–20. doi:10.1128/JVI.69.3.1612-1620.1995. PMC 188757. PMID 7853496.
Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–84. doi:10.1128/JVI.70.7.4576-4584.1996. PMC 190394. PMID 8676484.
Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID 8800208.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
Okamoto H, Sheline CT, Corden JL, et al. (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi:10.1073/pnas.93.21.11575. PMC 38099. PMID 8876177.
Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–94. doi:10.1074/jbc.271.44.27888. PMID 8910388.
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/MCB.17.4.1817. PMC 232028. PMID 9121429.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168002 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071662 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7579693-5] Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell. 6 (7): 759–75. doi:10.1091/mbc.6.7.759. PMC 301239. PMID 7579693.

[pmid9256063-6] Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta. 1353 (1): 39–49. doi:10.1016/s0167-4781(97)00041-9. PMID 9256063.

[7] "Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G".

[pmid9488465-8] Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. UNITED STATES. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863. PMID 9488465.

[pmid9201987-9] Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

POLR2G

Interactions

References

Further reading