POLR2L

DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene.[5]

POLR2L
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2L, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, polymerase (RNA) II subunit L, RNA polymerase II subunit L, RNA polymerase II, I and III subunit L
External IDsOMIM: 601189 MGI: 1913741 HomoloGene: 129854 GeneCards: POLR2L
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start837,356 bp[1]
End842,529 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5441

66491

Ensembl

ENSG00000177700

ENSMUSG00000038489

UniProt

P62875

P62876

RefSeq (mRNA)

NM_021128

NM_025593

RefSeq (protein)

NP_066951

NP_079869

Location (UCSC)Chr 11: 0.84 – 0.84 MbChr 7: 141.47 – 141.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.[6]

Interactions

POLR2L has been shown to interact with POLR2C,[7] POLR2A,[7] POLR2B[7] and POLR2E.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000177700 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038489 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (September 1996). "The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase". Genomics. 32 (1): 86–90. doi:10.1006/geno.1996.0079. PMID 8786124.
  6. "Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa".
  7. Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987.

Further reading


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