PPP1CC

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.[5]

PPP1CC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP1CC, PP-1G, PP1C, PPP1G, protein phosphatase 1 catalytic subunit gamma
External IDsOMIM: 176914 MGI: 3647492 HomoloGene: 100608 GeneCards: PPP1CC
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.11Start110,719,680 bp[1]
End110,742,939 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5501

434233

Ensembl

ENSG00000186298

ENSMUSG00000004455

UniProt

P36873

P63087

RefSeq (mRNA)

NM_001244974
NM_002710

XM_006508415

RefSeq (protein)

NP_001231903
NP_002701

NP_038664

Location (UCSC)Chr 12: 110.72 – 110.74 MbChr 5: 122.16 – 122.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PPP1CC has been shown to interact with PPP1R15A,[6][7] SMARCB1,[6] TLX1[8] and PPP1R9B.[9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000186298 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004455 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".
  6. Wu, Daniel Y; Tkachuck Douglas C; Roberson Rachel S; Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. United States. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
  7. Connor, J H; Weiser D C; Li S; Hallenbeck J M; Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. United States. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.
  8. Kawabe, T; Muslin A J; Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. ENGLAND. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.
  9. Hsieh-Wilson, L C; Allen P B; Watanabe T; Nairn A C; Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. UNITED STATES. 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
  10. Smith, F D; Oxford G S; Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. UNITED STATES. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.

Further reading

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