PPP1R9A

PPP1R9A
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1WF8
Identifiers
Aliases	PPP1R9A, NRB1, NRBI, Neurabin-I, protein phosphatase 1 regulatory subunit 9A
External IDs	OMIM: 602468 MGI: 2442401 HomoloGene: 14247 GeneCards: PPP1R9A
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	95,296,415 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	5,165,661 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • protein domain specific binding; • protein phosphatase 1 binding; • GO:0001948 protein binding; • GTPase binding; • actin binding; • actin filament binding; • protein C-terminus binding; • protein kinase binding; • ion channel binding; • GO:0032403 macromolecular complex binding;
Cellular component	• dendritic spine neck; • cytosol; • filopodium; • growth cone; • neuromuscular junction; • dendritic spine; • synapse; • growth cone lamellipodium; • cell junction; • neuronal cell body; • cortical actin cytoskeleton; • neuron projection; • cytoskeleton; • lamellipodium; • cytoplasm; • GO:0097483, GO:0097481 postsynaptic density; • actin cytoskeleton; • dendrite; • postsynaptic actin cytoskeleton; • glutamatergic synapse;
Biological process	• regulation of filopodium assembly; • cell differentiation; • regulation of synapse structural plasticity; • regulation of synapse assembly; • aging; • cellular response to toxic substance; • neuron development; • positive regulation of dendritic spine development; • nervous system development; • multicellular organism development; • regulation of actin filament polymerization; • excitatory postsynaptic potential; • negative regulation of long-term synaptic potentiation; • negative regulation of spontaneous neurotransmitter secretion; • positive regulation of long term synaptic depression; • positive regulation of neuron projection development; • negative regulation of stress fiber assembly; • regulation of dendritic spine morphogenesis; • positive regulation of protein kinase activity; • actin filament organization; • calcium-mediated signaling; • neuron projection development; • modulation of chemical synaptic transmission; • postsynaptic actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	55607
	243725
	ENSG00000158528
	ENSMUSG00000032827
	Q9ULJ8
	n/a
	NM_001166160; NM_001166161; NM_001166162; NM_001166163; NM_017650
	NM_181595; NM_001363809
NP_001159632; NP_001159633; NP_001159634; NP_001159635; NP_060120;
	NP_001159635.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000158528 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032827 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
"Entrez Gene: PPP1R9A protein phosphatase 1, regulatory (inhibitor) subunit 9A".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Nakanishi H, Obaishi H, Satoh A, et al. (1997). "Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation". J. Cell Biol. 139 (4): 951–61. doi:10.1083/jcb.139.4.951. PMC 2139968. PMID 9362513.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
McAvoy T, Allen PB, Obaishi H, et al. (1999). "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation". Biochemistry. 38 (39): 12943–9. doi:10.1021/bi991227d. PMID 10504266.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
Oliver CJ, Terry-Lorenzo RT, Elliott E, et al. (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC 133892. PMID 12052877.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158528 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032827 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574462-5] Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

[entrez-6] "Entrez Gene: PPP1R9A protein phosphatase 1, regulatory (inhibitor) subunit 9A".

PPP1R9A

References

Further reading