PSCDBP

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.[5][6][7][8]

CYTIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCYTIP, B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP, cytohesin 1 interacting protein
External IDsOMIM: 604448 MGI: 2183535 HomoloGene: 3167 GeneCards: CYTIP
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q24.1Start157,414,619 bp[1]
End157,488,961 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9595

227929

Ensembl

ENSG00000115165

ENSMUSG00000026832

UniProt

O60759

Q91VY6

RefSeq (mRNA)

NM_004288

NM_139200

RefSeq (protein)

NP_004279

NP_631939

Location (UCSC)Chr 2: 157.41 – 157.49 MbChr 2: 58.13 – 58.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000115165 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026832 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.
  6. Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 95. doi:10.1159/000015226. PMID 10343115. S2CID 7420858.
  7. Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.
  8. "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

Further reading


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