PTBP2

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.[5][6]

PTBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDsOMIM: 608449 MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p21.3Start96,721,665 bp[1]
End96,823,738 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

58155

56195

Ensembl

ENSG00000117569

ENSMUSG00000028134

UniProt

Q9UKA9

Q91Z31

RefSeq (mRNA)

NM_019550
NM_001310711

RefSeq (protein)

NP_001297640
NP_062423

Location (UCSC)Chr 1: 96.72 – 96.82 MbChr 3: 119.72 – 119.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000117569 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028134 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
  6. "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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