PUF60

Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.[5][6][7][8]

PUF60
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPUF60, FIR, RoBPI, SIAHBP1, VRJS, poly(U) binding splicing factor 60KDa, poly(U) binding splicing factor 60
External IDsOMIM: 604819 MGI: 1915209 HomoloGene: 8614 GeneCards: PUF60
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start143,816,344 bp[1]
End143,829,352 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22827

67959

Ensembl

ENSG00000179950
ENSG00000274081

ENSMUSG00000002524

UniProt

Q9UHX1

Q3UEB3

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 8: 143.82 – 143.83 MbChr 15: 76.07 – 76.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.[8]

Interactions

PUF60 has been shown to interact with U2AF2.[9][10]

References

  1. ENSG00000274081 GRCh38: Ensembl release 89: ENSG00000179950, ENSG00000274081 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002524 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bouffard P, Barbar E, Brière F, Boire G (January 2000). "Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins". RNA. 6 (1): 66–78. doi:10.1017/S1355838200990277. PMC 1369894. PMID 10668799.
  6. Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D (February 2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Molecular Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
  7. Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR (June 2007). Valcarcel J (ed.). "Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)". PLOS ONE. 2 (6): e538. Bibcode:2007PLoSO...2..538H. doi:10.1371/journal.pone.0000538. PMC 1888729. PMID 17579712.
  8. "Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor".
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Poly(U)-binding-splicing factor PUF60



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