PUM2

Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene.[5][6][7][8]

PUM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPUM2, PUMH2, PUML2, pumilio RNA binding family member 2
External IDsOMIM: 607205 MGI: 1931751 HomoloGene: 69183 GeneCards: PUM2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p24.1Start20,248,691 bp[1]
End20,352,234 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23369

80913

Ensembl

ENSG00000055917

ENSMUSG00000020594

UniProt

Q8TB72

Q80U58

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 2: 20.25 – 20.35 MbChr 12: 8.67 – 8.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PUM2 has been shown to interact with the following proteins:

References

  1. GRCh38: Ensembl release 89: ENSG00000055917 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020594 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  6. Spassov DS, Jurecic R (Dec 2002). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene. 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID 12459267.
  7. Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA (Jan 2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins". Proc Natl Acad Sci U S A. 100 (2): 538–43. doi:10.1073/pnas.0234478100. PMC 141031. PMID 12511597.
  8. "Entrez Gene: PUM2 pumilio homolog 2 (Drosophila)".
  9. Campbell ZT, Menichelli E, Friend K, Wu J, Kimble J, Williamson JR, Wickens M (2012). "Identification of a conserved interface between PUF and CPEB proteins". J Biol Chem. 287 (22): 18854–62. doi:10.1074/jbc.M112.352815. PMC 3365739. PMID 22496444.
  10. Ota R, Kotani T, Yamashita M (2011). "Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes". J Biol Chem. 286 (4): 2853–63. doi:10.1074/jbc.M110.155523. PMC 3024781. PMID 21098481.
  11. Haston KM, Tung JY, Reijo Pera RA (2009). "Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro". PLOS ONE. 4 (5): e5654. doi:10.1371/journal.pone.0005654. PMC 2681483. PMID 19468308.
  12. Geyer CB, Saba R, Kato Y, Anderson AJ, Chappell VK, Saga Y, Eddy EM (2012). "Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male". Biol Reprod. 86 (4): 127. doi:10.1095/biolreprod.111.094938. PMC 3338663. PMID 22190708.

Further reading


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