Peter J. H. Scott

Peter J. H. Scott FRSC CChem (born 27 July 1979) is a British and American chemist and radiochemist who is an Associate Professor of Radiology and Pharmacology, as well as a Faculty Scientist in the Interdepartmental Program in Medicinal Chemistry and a Core Member of the Rogel Cancer Center at the University of Michigan in the United States.[1][2] He is director of the University of Michigan Positron Emission Tomography (PET) Center,[3] and runs a research group developing new radiochemistry methodology and novel PET radiotracers.[4]

Peter Scott
BornJuly 27, 1979
CitizenshipBritish and American
Alma materLoughborough University Durham University
AwardsAcademy for Radiology & Biomedical Imaging Research: 2019 Distinguished Investigator Award
Scientific career
FieldsChemistry
Radiochemistry
Positron emission tomography
Nuclear Medicine
InstitutionsUniversity of Michigan
ThesisPerfluoroalkanesulfonyl linker units for solid phase organic synthesis
Doctoral advisorPatrick G. Steel
Other academic advisorsHuw Davies (chemist)

Life

Peter Scott was born and grew up in North East England and attended Whitley Bay High School. He received his undergraduate degree with first class honors in medicinal and pharmaceutical chemistry from Loughborough University in 2001, after conducting research with Raymond Jones. He subsequently obtained his PhD in organic chemistry from Durham University in 2005, where he was a member of Ustinov College, under the mentorship of Patrick G. Steel. Scott then moved to the United States to undertake postdoctoral research in organometallic chemistry at SUNY Buffalo under Huw Davies, and PET radiochemistry at the University of Michigan with Michael Kilbourn.

Research

Scott runs a research group developing new metal-catalyzed methods for incorporating fluorine-18 and carbon-11 into bioactive molecules as well as novel PET radiotracers for imaging neurodegenerative disorders. His methodology work aims to improve the synthesis of PET radiotracers and he has an active collaboration with Prof. Melanie Sanford's group[5] that is funded by NIBIB.[6] Together they have developed methods for the Cu-mediated radiofluorination[7] and radiocyanation of (mesityl)(aryl)iodonium salts,[8] boronic acids[9][10] and stannanes,[10][11] as well as new methods for radiofluorination of C-H bonds[12][13][14] and aryl halides.[15] Scott has also introduced methods for green radiochemistry,[16] for which he received the Michigan Green Chemistry Governor's Award in 2014.[17] In 2019, Prof. Scott was elected as a Fellow of the Royal Society of Chemistry (FRSC),[18] and received a Distinguished Investigator Award from the Academy for Radiology & Biomedical Imaging Research.[19]

Bibliography

1. Linker Strategies in Solid-phase Organic Synthesis (Editor, 2009)[20]
2. Solid-Phase Organic Syntheses, Volume 2: Solid-Phase Palladium Chemistry (Wiley Series on Solid-Phase Organic Syntheses) (Editor, 2012)[21]
3. Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1 (Editor, 2012)[22]
4. Radiochemical Syntheses: Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Volume 2 (Editor, 2015)[23]
5. Handbook of Radiopharmaceuticals (2nd Edition): Methodology and Applications (Editor, 2021)[24]

References
  1. "Radiology | Michigan Medicine | University of Michigan". medicine.umich.edu. Retrieved 2019-05-01.
  2. "Medicinal Chemistry | UM College of Pharmacy". pharmacy.umich.edu. Retrieved 2019-05-01.
  3. "PET Center | Radiology | Michigan Medicine | University of Michigan". medicine.umich.edu. Retrieved 2019-05-01.
  4. "Peter J. Scott profile". mcommunity.umich.edu.
  5. Haynes, Sarah (October 3, 2018). "UM scientists improve synthesis of PET imaging molecules". lsa.umich.edu.
  6. https://grantome.com/grant/NIH/R01-EB021155-04
  7. Wright, Jay S.; Kaur, Tanpreet; Preshlock, Sean; Tanzey, Sean S.; Winton, Wade P.; Sharninghausen, Liam S.; Wiesner, Nicholas; Brooks, Allen F.; Sanford, Melanie S.; Scott, Peter J. H. (2020-05-26). "Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging". Clinical and Translational Imaging. 8 (3): 167–206. doi:10.1007/s40336-020-00368-y. ISSN 2281-5872.
  8. Ichiishi, Naoko; Brooks, Allen F.; Topczewski, Joseph J.; Rodnick, Melissa E.; Sanford, Melanie S.; Scott, Peter J. H. (2014-06-20). "Copper-Catalyzed [ 18 F]Fluorination of (Mesityl)(aryl)iodonium Salts". Organic Letters. 16 (12): 3224–3227. doi:10.1021/ol501243g. ISSN 1523-7060. PMC 4076000. PMID 24890658.
  9. Mossine, Andrew V.; Brooks, Allen F.; Makaravage, Katarina J.; Miller, Jason M.; Ichiishi, Naoko; Sanford, Melanie S.; Scott, Peter J. H. (2015-12-04). "Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids". Organic Letters. 17 (23): 5780–5783. doi:10.1021/acs.orglett.5b02875. ISSN 1523-7060. PMC 4672358. PMID 26568457.
  10. Makaravage, Katarina J.; Shao, Xia; Brooks, Allen F.; Yang, Lingyun; Sanford, Melanie S.; Scott, Peter J. H. (2018-02-27). "Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes". Organic Letters. 20 (6): 1530–1533. doi:10.1021/acs.orglett.8b00242. ISSN 1523-7060. PMC 5892454. PMID 29484880.
  11. Makaravage, Katarina J.; Brooks, Allen F.; Mossine, Andrew V.; Sanford, Melanie S.; Scott, Peter J. H. (2016-10-10). "Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF". Organic Letters. 18 (20): 5440–5443. doi:10.1021/acs.orglett.6b02911. ISSN 1523-7060. PMC 5078836. PMID 27718581.
  12. McCammant, Matthew S.; Thompson, Stephen; Brooks, Allen F.; Krska, Shane W.; Scott, Peter J. H.; Sanford, Melanie S. (2017-07-21). "Cu-Mediated C–H 18F-Fluorination of Electron-Rich (Hetero)arenes". Organic Letters. 19 (14): 3939–3942. doi:10.1021/acs.orglett.7b01902. ISSN 1523-7060. PMC 5525103. PMID 28665619.
  13. Lee, So Jeong; Makaravage, Katarina J.; Brooks, Allen F.; Scott, Peter J. H.; Sanford, Melanie S. (2019-01-18). "Copper-Mediated Aminoquinoline-Directed Radiofluorination of Aromatic C−H Bonds with K18F". Angewandte Chemie International Edition. 58 (10): 3119–3122. doi:10.1002/anie.201812701. ISSN 1433-7851. PMC 6476334. PMID 30605563.
  14. Lee, So Jeong; Brooks, Allen F.; Ichiishi, Naoko; Makaravage, Katarina J.; Mossine, Andrew V.; Sanford, Melanie S.; Scott, Peter J. H. (2019). "C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F". Chemical Communications. 55 (20): 2976–2979. doi:10.1039/c9cc00641a. ISSN 1359-7345. PMC 6556205. PMID 30778496.
  15. Sharninghausen, Liam S.; Brooks, Allen F.; Winton, Wade P.; Makaravage, Katarina J.; Scott, Peter J. H.; Sanford, Melanie S. (2020). "NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides". Journal of the American Chemical Society. 142 (16): 7362–7367. doi:10.1021/jacs.0c02637. ISSN 0002-7863. PMC 7314054. PMID 32250612.
  16. Stewart, Megan N.; Hockley, Brian G.; Scott, Peter J. H. (2015). "Green approaches to late-stage fluorination: radiosyntheses of 18F-labelled radiopharmaceuticals in ethanol and water". Chemical Communications. 51 (79): 14805–14808. doi:10.1039/c5cc05919d. ISSN 1359-7345. PMID 26300287.
  17. "Michigan Green Chemistry Governor's Awards Program". michigan.gov.
  18. Fellows. The Times, 12 March 2019, p. 55, col. E&F.
  19. "The Academy for Radiology & Biomedical Imaging Research Announces the Recipients of its Eighth Annual Distinguished Investigator Award" (PDF). acadrad.org.
  20. Linker Strategies in Solid-phase Organic Synthesis; https://onlinelibrary.wiley.com/doi/book/10.1002/9780470749043
  21. Solid-Phase Organic Syntheses, Volume 2: Solid-Phase Palladium Chemistry (Wiley Series on Solid-Phase Organic Syntheses); https://onlinelibrary.wiley.com/doi/book/10.1002/9781118336953
  22. Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography, Volume 1; https://onlinelibrary.wiley.com/doi/book/10.1002/9781118140345
  23. Radiochemical Syntheses: Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Volume 2; https://onlinelibrary.wiley.com/doi/book/10.1002/9781118834114
  24. Handbook of Radiopharmaceuticals; https://onlinelibrary.wiley.com/doi/book/10.1002/9781119500575
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