Phenylpiperidine

Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity[1] or other central nervous system effects.

"Phenyl"piperidines
Compound	N	4-position	3-position	4'-position	Type of pharmacology
MPPP	Me	Ph	H	-OCOEt	Opioid analgesic
Prodine	Me	Ph	Me	-OCOEt	Opioid analgesic
PEPAP	CH₂CH₂Ph	Ph	H	-OCOMe	Opioid analgesic
Pethidine	Me	Ph	H	-CO₂Et	mu-Agonist with serotonin reuptake inhibitor properties
Budipine	t-Bu	Ph	H	Ph	Antiparkinson agent
Ketobemidone	Me	3-HO-Ph	H	-COEt	Opioid and NMDA antagonist
Paroxetine	H	4-F-Ph	-CH₂OAr[lower-alpha 1]	H	Selective serotonin reuptake inhibitor (and norepinephrine transporter)
Femoxetine	Me	Ph	-CH₂O(4-MeOPh)	H	Selective serotonin reuptake inhibitor
CPCA	Me	4-Cl-Ph	-CO₂Me	H	Monoamine reuptake inhibitor

Ar denotes an aryl group; here specifically being benzodioxol-3-yl.

Methylphenidate is a benzylpiperidine.

References

Janssen, PA (April 1962). "A Review of the Chemical Features Associated with Strong Morphine-Like Activity". British Journal of Anaesthesia. 34 (4): 260–268. doi:10.1093/bja/34.4.260. PMID 14451235.

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[2] Ar denotes an aryl group; here specifically being benzodioxol-3-yl.

[1] Janssen, PA (April 1962). "A Review of the Chemical Features Associated with Strong Morphine-Like Activity". British Journal of Anaesthesia. 34 (4): 260–268. doi:10.1093/bja/34.4.260. PMID 14451235.