Picornavirus internal ribosome entry site (IRES)

This family represents the Picornavirus internal ribosome entry site (IRES) element present in their 5' untranslated region.[1] These elements were discovered in picornaviruses.[2] They are cis-acting RNA sequences that adopt diverse three-dimensional structures, recruit the translation machinery and that often operate in association with specific RNA-binding proteins.[2] IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[3][4] Based on their secondary structure, picornavirus IRES are grouped into four main types. Type I comprises enteroand rhinovirus IRES and type II, those of cardio- and aphthovirus, among others. Type III is used to name hepatitis A IRES.[2]

Picornavirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Picorna
Identifiers
SymbolIRES_Picorna
RfamRF00229
Other data
RNA typeCis-reg; IRES
Domain(s)Viruses
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

References
  1. Fernández-Miragall, Olga; Quinto, Sonia López de; Martínez-Salas, Encarnación (February 2009). "Relevance of RNA structure for the activity of picornavirus IRES elements". Virus Research. 139 (2): 172–182. doi:10.1016/j.virusres.2008.07.009. PMID 18692097.
  2. Martínez-Salas, Encarnación; Francisco-Velilla, Rosario; Fernandez-Chamorro, Javier; Lozano, Gloria; Diaz-Toledano, Rosa (August 2015). "Picornavirus IRES elements: RNA structure and host protein interactions". Virus Research. 206: 62–73. doi:10.1016/j.virusres.2015.01.012. hdl:10261/140186. PMID 25617758.
  3. Ray PS, Das S (October 2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Research. 30 (20): 4500–4508. doi:10.1093/nar/gkf583. PMC 137146. PMID 12384597.
  4. Liu Z, Carthy CM, Cheung P, Bohunek L, Wilson JE, McManus BM, Yang D (December 1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology. 265 (2): 206–217. doi:10.1006/viro.1999.0048. PMID 10600593.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.