Prolactin-releasing peptide

Prolactin-releasing peptide (PrRP) is a peptide hormone that in humans is encoded by the PRLH gene.[5] PrRP stimulates prolactin (PRL) release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor (GPR10).[6]

PRLH
Identifiers
AliasesPRLH, PRH, PRRP, prolactin releasing hormone
External IDsOMIM: 602663 MGI: 3644668 HomoloGene: 9291 GeneCards: PRLH
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q37.3Start237,566,574 bp[1]
End237,567,175 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51052

623503

Ensembl

ENSG00000071677

ENSMUSG00000090550

UniProt

P81277

G3UWC3

RefSeq (mRNA)

NM_015893

NM_001101647

RefSeq (protein)

NP_056977

NP_001095117

Location (UCSC)Chr 2: 237.57 – 237.57 MbChr 1: 90.95 – 90.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Description

PrRP has 20 amino acids, and is a member of the RFamide peptide family.

During the discovery process, PrRP was found to be a ligand for an orphan G-protein coupled receptor (GPR 10). Preliminary in vitro studies showed it to stimulate the secretion of prolactin from lactotropic cells, hence its name. Now, however, the function of PrRP in the brain is understood in terms of negative regulation of appetite.[7]

PrRP is produced by noradrenergic neurons A1 and A2 in the solitary nucleus, and also by neurons in the hypothalamus.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000071677 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000090550 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PRLH prolactin releasing hormonel".
  6. Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ (October 2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC 1572376. PMID 11030716.
  7. Brunton, Paula; Russell, John (2015). Physiology of Reproduction (Fourth ed.). Academic Press. doi:10.1016/C2011-1-07288-0. ISBN 978-0-12-397175-3. Retrieved April 29, 2020. (This extract is more helpful.)

Further reading


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