QST (genetics)

In quantitative genetics, QST is a statistic intended to measure the degree of genetic differentiation among populations with regard to a quantitative trait. It was developed by Ken Spitze in 1993.[1] Its name reflects the fact that it was intended to be analogous to the fixation index for a single genetic locus, which is denoted FST.[2][3] QST is often compared with FST to test the hypothesis that a given quantitative trait has been the subject of divergent selection between the populations being studied. Generally, if QST is found to exceed FST, this is interpreted as evidence of such divergent selection, because it indicates that there is more differentiation in the trait than could be produced solely by genetic drift. By contrast, if the values of QST and FST in the same study are approximately equal, it is considered to reflect that the observed trait differentiation could be entirely due to genetic drift. However, the assumptions on which studies using this methodology (known as QST–FST comparisons) are based have been questioned.[4][5][6]

References
  1. Spitze K (October 1993). "Population structure in Daphnia obtusa: quantitative genetic and allozymic variation". Genetics. 135 (2): 367–74. PMC 1205642. PMID 8244001.
  2. Whitlock MC (April 2008). "Evolutionary inference from QST". Molecular Ecology. 17 (8): 1885–96. doi:10.1111/j.1365-294X.2008.03712.x. PMID 18363667.
  3. McKay, John K.; Latta, Robert G. (June 2002). "Adaptive population divergence: markers, QTL and traits". Trends in Ecology & Evolution. 17 (6): 285–291. doi:10.1016/S0169-5347(02)02478-3.
  4. Pujol B, Wilson AJ, Ross RI, Pannell JR (November 2008). "Are Q(ST)−F(ST) comparisons for natural populations meaningful?". Molecular Ecology. 17 (22): 4782–5. doi:10.1111/j.1365-294X.2008.03958.x. PMID 19140971.
  5. Leinonen T, O'Hara RB, Cano JM, Merilä J (January 2008). "Comparative studies of quantitative trait and neutral marker divergence: a meta-analysis". Journal of Evolutionary Biology. 21 (1): 1–17. doi:10.1111/j.1420-9101.2007.01445.x. PMID 18028355.
  6. Miller JR, Wood BP, Hamilton MB (October 2008). "F(ST) and Q(ST) under neutrality". Genetics. 180 (2): 1023–37. doi:10.1534/genetics.108.092031. PMC 2567353. PMID 18780742.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.