RAB6A

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome.[5] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

RAB6A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAB6A, RAB6, member RAS oncogene family
External IDsOMIM: 179513 MGI: 894313 HomoloGene: 55697 GeneCards: RAB6A
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.4Start73,675,638 bp[1]
End73,761,137 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5870

19346

Ensembl

ENSG00000175582

ENSMUSG00000030704

UniProt

P20340

P35279

RefSeq (mRNA)

NM_198896
NM_001243718
NM_001243719
NM_002869

NM_001163663
NM_024287

RefSeq (protein)

NP_001230647
NP_001230648
NP_002860
NP_942599

NP_001157135
NP_077249

Location (UCSC)Chr 11: 73.68 – 73.76 MbChr 7: 100.61 – 100.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RAB6A has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000175582 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030704 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RAB6A RAB6A, member RAS oncogene family".
  6. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177.
  7. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.
  8. Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
  9. Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
  10. Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

Further reading


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