RABEP1

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene.[5][6] It belongs to rabaptin protein family.

RABEP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRABEP1, RAB5EP, RABPT5, rabaptin, RAB GTPase binding effector protein 1
External IDsOMIM: 603616 MGI: 1860236 HomoloGene: 3451 GeneCards: RABEP1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.2Start5,282,265 bp[1]
End5,386,340 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9135

54189

Ensembl

ENSG00000029725

ENSMUSG00000020817

UniProt

Q15276

O35551

RefSeq (mRNA)

NM_001083585
NM_001291581
NM_001291582
NM_004703

NM_001291141
NM_001291142
NM_001291143
NM_019400

RefSeq (protein)

NP_001077054
NP_001278510
NP_001278511
NP_004694

NP_001278070
NP_001278071
NP_001278072
NP_062273

Location (UCSC)Chr 17: 5.28 – 5.39 MbChr 11: 70.84 – 70.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RABEP1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000029725 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020817 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stenmark H, Vitale G, Ullrich O, Zerial M (Nov 1995). "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell. 83 (3): 423–32. doi:10.1016/0092-8674(95)90120-5. PMID 8521472.
  6. "Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1".
  7. Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  8. Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
  9. Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540. PMID 9524117.
  10. Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry. 272 (10): 6097–100. doi:10.1074/jbc.272.10.6097. PMID 9045618.
  11. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716. S2CID 21545088.

Further reading


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