RANBP3

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.[5][6]

RANBP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRANBP3, RAN binding protein 3
External IDsOMIM: 603327 MGI: 1919060 HomoloGene: 136516 GeneCards: RANBP3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start5,916,139 bp[1]
End5,978,142 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8498

71810

Ensembl

ENSG00000031823

ENSMUSG00000002372

UniProt

Q9H6Z4

Q9CT10

RefSeq (mRNA)

NM_001300865
NM_003624
NM_007320
NM_007321
NM_007322

NM_001252466
NM_001252467
NM_027933

RefSeq (protein)

NP_001287794
NP_003615
NP_015559
NP_015561

NP_001239395
NP_001239396
NP_082209

Location (UCSC)Chr 19: 5.92 – 5.98 MbChr 17: 56.67 – 56.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Interactions

RANBP3 has been shown to interact with RCC1[5][7] and XPO1.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000031823 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002372 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251. S2CID 28405923.
  6. "Entrez Gene: RANBP3 RAN binding protein 3".
  7. Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251.
  8. Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735. PMID 11425870.
  9. Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322. S2CID 15515037.

Further reading


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