RAP1GAP

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.[5][6]

RAP1GAP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAP1GAP, RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP, RAP1 GTPase activating protein
External IDsOMIM: 600278 MGI: 109338 HomoloGene: 2163 GeneCards: RAP1GAP
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.12Start21,596,215 bp[1]
End21,669,363 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5909

110351

Ensembl

ENSG00000076864

ENSMUSG00000041351

UniProt

P47736

A2ALS5

RefSeq (mRNA)

NM_001081155
NM_001256218
NM_029563
NM_001331215

RefSeq (protein)
Location (UCSC)Chr 1: 21.6 – 21.67 MbChr 4: 137.66 – 137.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RAP1GAP has been shown to interact with MLLT4.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000076864 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041351 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P (June 1991). "Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1". Cell. 65 (6): 1033–42. doi:10.1016/0092-8674(91)90555-D. PMID 1904317. S2CID 45725280.
  6. "Entrez Gene: RAP1GAP RAP1 GTPase activating protein".
  7. Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N (April 2003). "AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1". The Journal of Biological Chemistry. 278 (17): 15232–8. doi:10.1074/jbc.M211888200. PMID 12590145.

Further reading

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