RAP1GDS1

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.[5][6][7]

RAP1GDS1
Identifiers
AliasesRAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDsOMIM: 179502 MGI: 2385189 HomoloGene: 41422 GeneCards: RAP1GDS1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q23Start98,261,384 bp[1]
End98,443,861 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5910

229877

Ensembl

ENSG00000138698

ENSMUSG00000028149

UniProt

P52306

n/a

RefSeq (mRNA)

NM_001040690
NM_001286759
NM_145544
NM_001356388

RefSeq (protein)

n/a

Location (UCSC)Chr 4: 98.26 – 98.44 MbChr 3: 138.93 – 139.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

RAP1GDS1 has been shown to interact with KIFAP3,[8] HRAS[9] and RHOA.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000138698 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028149 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526. S2CID 21189125.
  6. Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.
  7. "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
  8. Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.
  9. Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427.

Further reading


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