RAPGEF2

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.[5][6][7]

RAPGEF2
Identifiers
AliasesRAPGEF2, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP, Rap guanine nucleotide exchange factor 2, RAGEF
External IDsOMIM: 609530 MGI: 2659071 HomoloGene: 35477 GeneCards: RAPGEF2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.1Start159,103,013 bp[1]
End159,360,174 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9693

76089

Ensembl

ENSG00000109756

ENSMUSG00000062232

UniProt

Q9Y4G8

Q8CHG7

RefSeq (mRNA)

NM_001099624
NM_001310536

RefSeq (protein)

NP_001093094
NP_001297465

Location (UCSC)Chr 4: 159.1 – 159.36 MbChr 3: 79.06 – 79.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAPGEF2 is a cyclic AMP binding protein.[8][9]

Function

Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.[6]

Interactions

RAPGEF2 has been shown to interact with RAP1A[6] and RALGDS.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000109756 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062232 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  6. Rebhun JF, Castro AF, Quilliam LA (November 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J Biol Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
  7. "Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2".
  8. Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D (May 2000). "The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP". Curr. Biol. 10 (9): 555–8. doi:10.1016/S0960-9822(00)00473-5. PMID 10801446. S2CID 16896523.
  9. Emery AC, Eiden MV, Mustafa T, Eiden LE (2013). "Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells". Sci Signal. 6 (281): ra51. doi:10.1126/scisignal.2003993. PMC 3932028. PMID 23800469.
  10. Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.

Further reading


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