RAPGEF5

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.[5][6][7]

RAPGEF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5
External IDsOMIM: 609527 MGI: 2444365 HomoloGene: 56563 GeneCards: RAPGEF5
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p15.3Start22,118,236 bp[1]
End22,357,154 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9771

217944

Ensembl

ENSG00000136237

ENSMUSG00000041992

UniProt

Q92565

Q8C0Q9

RefSeq (mRNA)

NM_012294
NM_001367600
NM_001367601
NM_001367602
NM_001367603

NM_175930
NM_001373989

RefSeq (protein)

NP_036426
NP_001354529
NP_001354530
NP_001354531
NP_001354532

NP_787126
NP_001360918

Location (UCSC)Chr 7: 22.12 – 22.36 MbChr 12: 117.52 – 117.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000136237 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041992 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  6. Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569. S2CID 20296877.
  7. "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

Further reading


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